RATIONALE: Interferon alfa may interfere with the growth of the cancer cells and slow the
growth of kidney cancer. Isotretinoin may help kidney cancer cells develop into normal
cells. It is not yet known whether interferon alfa plus isotretinoin is more effective than
interferon alfa alone for kidney cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of interferon alfa with or
without isotretinoin in treating patients who have metastatic kidney cancer.
Minimum age: 18 Years.
Maximum age: 75 Years.
Gender(s): Both.
Onze Lieve Vrouw Ziekenhuis Aalst, Aalst B-9300, Belgium
Algemeen Ziekenhuis Middelheim, Antwerp 2020, Belgium
Institut Jules Bordet, Brussels 1000, Belgium
Universitair Ziekenhuis Antwerpen, Edegem B-2650, Belgium
U.Z. Gasthuisberg, Leuven B-3000, Belgium
National Institute of Oncology, Budapest 1125, Hungary
Ospedale di Circolo e Fondazione Macchi, Varese 21100, Italy
Academisch Medisch Centrum, Amsterdam 1105 AZ, Netherlands
Antoni van Leeuwenhoekhuis, Amsterdam 1066 CX, Netherlands
Groot Ziekengasthuis 's-Hertogenbosch, Hertogenbosch 5211 NL, Netherlands
Leiden University Medical Center, Leiden 2300 CA, Netherlands
University Medical Center Nijmegen, Nijmegen NL-6252 HB, Netherlands
Rotterdam Cancer Institute, Rotterdam 3075 EA, Netherlands
University Hospital - Rotterdam Dijkzigt, Rotterdam 3000 CA, Netherlands
Academisch Ziekenhuis Utrecht, Utrecht 3508 GA, Netherlands
Norwegian Radium Hospital, Oslo N-0310, Norway
Russian Academy of Medical Sciences Cancer Research Center, Moscow 115478, Russian Federation
Kantonspital Aarau, Aarau 5001, Switzerland
Ospedale San Giovanni, Bellinzona CH-6500, Switzerland
Inselspital, Bern, Bern CH-3010, Switzerland
Ratisches Kantons und Regionalspital, Chur CH-7000, Switzerland
Centre Hospitalier Universitaire Vaudois, Lausanne CH-1011, Switzerland
Kantonsspital - Saint Gallen, Saint Gallen CH-9007, Switzerland
Universitaetsspital, Zurich CH-8091, Switzerland
Marmara University Hospital, Istanbul 81190, Turkey
Bristol Royal Infirmary, Bristol, England BS2 8HW, United Kingdom
Beatson Oncology Centre, Glasgow, Scotland G11 6NT, United Kingdom