The Acute, Synergistic Effects of Protein and Calcium on Appetite and Energy Intake
Information source: Northumbria University
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Healthy
Intervention: Protein (Dietary Supplement); Calcium (Dietary Supplement); Porridge-based breakfast. (Dietary Supplement)
Phase: N/A
Status: Active, not recruiting
Sponsored by: Northumbria University Official(s) and/or principal investigator(s): Javier T Gonzalez, PhD, Principal Investigator, Affiliation: Northumbria University
Summary
High-protein meals have previously been shown to acutely reduce appetite and energy intake.
More recently, meals higher in calcium have also been shown to increase feelings of
fullness, circulating insulin and intestinal peptide concentrations and reduce appetite
sensations.
This study aims to assess whether calcium and protein act synergistically to acutely
influence appetite and energy intake.
Clinical Details
Official title: The Acute, Synergistic Effects of Protein and Calcium on Appetite and Energy Intake
Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science
Primary outcome: Energy Intake
Secondary outcome: Subjective appetite sensationsInsulin concentrations GLP-1 (7-36) concentrations GIP concentration
Eligibility
Minimum age: 18 Years.
Maximum age: 40 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Male or Female
- BMI 18. 5-29. 9 kg/m2
- Age: 18-40 years
Exclusion Criteria:
- Smokers
- Food allergies
- Metabolic disorders (ie. type 2 diabetes)
Locations and Contacts
Northumbria University, Newcastle upon Tyne, Tyne and Wear NE1 8ST, United Kingdom
Additional Information
Related publications: Astbury NM, Stevenson EJ, Morris P, Taylor MA, Macdonald IA. Dose-response effect of a whey protein preload on within-day energy intake in lean subjects. Br J Nutr. 2010 Dec;104(12):1858-67. doi: 10.1017/S000711451000293X. Epub 2010 Sep 28. Gonzalez JT, Rumbold PL, Stevenson EJ. Appetite sensations and substrate metabolism at rest, during exercise, and recovery: impact of a high-calcium meal. Appl Physiol Nutr Metab. 2013 Dec;38(12):1260-7. doi: 10.1139/apnm-2013-0056. Epub 2013 Jun 18. Gonzalez JT, Stevenson EJ. Calcium co-ingestion augments postprandial glucose-dependent insulinotropic peptide(1-42), glucagon-like peptide-1 and insulin concentrations in humans. Eur J Nutr. 2014;53(2):375-85. doi: 10.1007/s00394-013-0532-8. Epub 2013 May 21.
Starting date: November 2013
Last updated: April 18, 2014
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