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The Acute, Synergistic Effects of Protein and Calcium on Appetite and Energy Intake

Information source: Northumbria University
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Healthy

Intervention: Protein (Dietary Supplement); Calcium (Dietary Supplement); Porridge-based breakfast. (Dietary Supplement)

Phase: N/A

Status: Active, not recruiting

Sponsored by: Northumbria University

Official(s) and/or principal investigator(s):
Javier T Gonzalez, PhD, Principal Investigator, Affiliation: Northumbria University

Summary

High-protein meals have previously been shown to acutely reduce appetite and energy intake. More recently, meals higher in calcium have also been shown to increase feelings of fullness, circulating insulin and intestinal peptide concentrations and reduce appetite sensations. This study aims to assess whether calcium and protein act synergistically to acutely influence appetite and energy intake.

Clinical Details

Official title: The Acute, Synergistic Effects of Protein and Calcium on Appetite and Energy Intake

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Primary outcome: Energy Intake

Secondary outcome:

Subjective appetite sensations

Insulin concentrations

GLP-1 (7-36) concentrations

GIP concentration

Eligibility

Minimum age: 18 Years. Maximum age: 40 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Male or Female

- BMI 18. 5-29. 9 kg/m2

- Age: 18-40 years

Exclusion Criteria:

- Smokers

- Food allergies

- Metabolic disorders (ie. type 2 diabetes)

Locations and Contacts

Northumbria University, Newcastle upon Tyne, Tyne and Wear NE1 8ST, United Kingdom
Additional Information

Related publications:

Astbury NM, Stevenson EJ, Morris P, Taylor MA, Macdonald IA. Dose-response effect of a whey protein preload on within-day energy intake in lean subjects. Br J Nutr. 2010 Dec;104(12):1858-67. doi: 10.1017/S000711451000293X. Epub 2010 Sep 28.

Gonzalez JT, Rumbold PL, Stevenson EJ. Appetite sensations and substrate metabolism at rest, during exercise, and recovery: impact of a high-calcium meal. Appl Physiol Nutr Metab. 2013 Dec;38(12):1260-7. doi: 10.1139/apnm-2013-0056. Epub 2013 Jun 18.

Gonzalez JT, Stevenson EJ. Calcium co-ingestion augments postprandial glucose-dependent insulinotropic peptide(1-42), glucagon-like peptide-1 and insulin concentrations in humans. Eur J Nutr. 2014;53(2):375-85. doi: 10.1007/s00394-013-0532-8. Epub 2013 May 21.

Starting date: November 2013
Last updated: April 18, 2014

Page last updated: August 20, 2015

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