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Effect of Brimonidine on Corneal Thickness

Information source: Augenarztpraxis Breisach
Information obtained from ClinicalTrials.gov on February 07, 2013
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Impact of Brimonidine on the Cornea

Intervention: brimonidine 0.1% (Drug); placebo (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: Augenarztpraxis Breisach

Official(s) and/or principal investigator(s):
Matthias Grueb, Priv. Doz. Dr., Study Director, Affiliation: Augenarztpraxis Breisach

Overall contact:
Matthias Grueb, Priv. Doz. Dr., Phone: 004976677766, Email: matthias.grueb@web.de

Summary

Brimonidine, an alpha-2 adrenoceptor agonist, is an effective and safe medication which is widely used in glaucoma treatment. Although it is known that it is quickly taken up by the cornea following topical administration and that the cornea has alpha-2 adrenoceptors there are only few studies available on the impact brimonidine has on the cornea. The aim of the study is to find out

1. whether topical administration of brimonidine results in interaction with corneal alpha-2 adrenoceptors in terms of an increase in corneal thickness and

2. whether there are any differences between the response corneal epithelium, stroma and endothelium show to alpha-2 adrenoceptor stimulation.

Clinical Details

Official title: Effect of Brimonidine on Corneal Thickness

Study design: Observational Model: Case Control, Time Perspective: Prospective

Primary outcome: corneal thickness

Secondary outcome: intraocular pressure

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- healthy, 18-99 years, normal ophthalmologic history, consent to participate in the

study

Exclusion Criteria:

- any serious medical or neurologic conditions and/or regular use of local or systemic

medications

Locations and Contacts

Matthias Grueb, Priv. Doz. Dr., Phone: 004976677766, Email: matthias.grueb@web.de

Augenarztpraxis, Breisach, Baden-Wuerttemberg 79206, Germany; Recruiting
Matthias Grueb, Priv. Doz. Dr., Phone: 004976677766, Email: matthias.grueb@web.de
Matthias Grueb, Priv. Doz. Dr., Principal Investigator
Additional Information

Starting date: December 2010
Last updated: December 2, 2010

Page last updated: February 07, 2013

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