DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Assessment of Left Ventricular Torsion by Echocardiography Study

Information source: The Cleveland Clinic
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Hypertrophic Cardiomyopathy

Phase: N/A

Status: Active, not recruiting

Sponsored by: The Cleveland Clinic

Official(s) and/or principal investigator(s):
Zoran Popovic, M.D., Principal Investigator, Affiliation: The Cleveland Clinic

Summary

The purpose of this study is to learn about the twisting or wringing motion of the heartbeat called torsion which can be seen on ultrasound. This study will help figure out if there is a difference in the how a heart twists at rest and with exercise in people with normal hearts compared to people with HCM (abnormally thickened heart muscle). Volunteers will have an echocardiogram (ultrasound of the heart) while lying on a bed both at rest and while peddling a wheel located at at the foot of the bed. The patients will take about 1 to 1 1/2 hours total and the study will be complete after this procedure.

Clinical Details

Official title: Assessment of LV Torsion by Tissue Doppler Echocardiography

Study design: Observational Model: Case Control, Time Perspective: Cross-Sectional

Primary outcome: Myocardial torsion as measured by tissue Doppler echocardiography

Detailed description: Left ventricular myocardial torsion (myocardial wringing motion) will be investigated by the use of tissue Doppler echocardiography in both normal and HCM (hypertrophic cardiomyopathy) patients. The objective of this study is to characterize the myocardial torsional behavior in normal and in HCM patients both at rest and while undergoing moderate physiological exercise. After a routine echocardiographic study, tissue Doppler echocardiogram will be performed before and during supine bicycle exercise. Stress EchoTM Bed with ergometer (supine bicycle) is used during exercise testing. Standard electrocardiogram and blood pressure will be monitored throughout the exercise testing. This procedure will take about 1 to 1 1/2 hours and will not involve any follow-up.

Eligibility

Minimum age: 18 Years. Maximum age: 70 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Male and female patients age 18 to 70 years

- Patients with hypertrophic cardiomyopathy

- Patients with the ability to exercise using a supine bicycle

- Ability to provide informed consent

Exclusion Criteria:

- Aortic valve stenosis classified as moderate to severe

- Severe left ventricular obstruction at rest (high gradients > 4m/second)

- Uncontrolled arrhythmias including atrial fibrillation, atrial flutter, frequent

premature ventricular ectopic beats

- History of sustained ventricular tachyarrhythmia at any time

Locations and Contacts

The Cleveland Clinic Foundation, Cleveland, Ohio 44195, United States
Additional Information

Starting date: June 2005
Last updated: October 22, 2008

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017