Assessment of Left Ventricular Torsion by Echocardiography Study
Information source: The Cleveland Clinic
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Hypertrophic Cardiomyopathy
Phase: N/A
Status: Active, not recruiting
Sponsored by: The Cleveland Clinic Official(s) and/or principal investigator(s):
Zoran Popovic, M.D., Principal Investigator, Affiliation: The Cleveland Clinic
Summary
The purpose of this study is to learn about the twisting or wringing motion of the heartbeat
called torsion which can be seen on ultrasound. This study will help figure out if there is
a difference in the how a heart twists at rest and with exercise in people with normal
hearts compared to people with HCM (abnormally thickened heart muscle). Volunteers will
have an echocardiogram (ultrasound of the heart) while lying on a bed both at rest and while
peddling a wheel located at at the foot of the bed. The patients will take about 1 to 1 1/2
hours total and the study will be complete after this procedure.
Clinical Details
Official title: Assessment of LV Torsion by Tissue Doppler Echocardiography
Study design: Observational Model: Case Control, Time Perspective: Cross-Sectional
Primary outcome: Myocardial torsion as measured by tissue Doppler echocardiography
Detailed description:
Left ventricular myocardial torsion (myocardial wringing motion) will be investigated by the
use of tissue Doppler echocardiography in both normal and HCM (hypertrophic cardiomyopathy)
patients. The objective of this study is to characterize the myocardial torsional behavior
in normal and in HCM patients both at rest and while undergoing moderate physiological
exercise.
After a routine echocardiographic study, tissue Doppler echocardiogram will be performed
before and during supine bicycle exercise. Stress EchoTM Bed with ergometer (supine
bicycle) is used during exercise testing. Standard electrocardiogram and blood pressure
will be monitored throughout the exercise testing. This procedure will take about 1 to 1
1/2 hours and will not involve any follow-up.
Eligibility
Minimum age: 18 Years.
Maximum age: 70 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Male and female patients age 18 to 70 years
- Patients with hypertrophic cardiomyopathy
- Patients with the ability to exercise using a supine bicycle
- Ability to provide informed consent
Exclusion Criteria:
- Aortic valve stenosis classified as moderate to severe
- Severe left ventricular obstruction at rest (high gradients > 4m/second)
- Uncontrolled arrhythmias including atrial fibrillation, atrial flutter, frequent
premature ventricular ectopic beats
- History of sustained ventricular tachyarrhythmia at any time
Locations and Contacts
The Cleveland Clinic Foundation, Cleveland, Ohio 44195, United States
Additional Information
Starting date: June 2005
Last updated: October 22, 2008
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