Does Intravitreal Injection of Triamcinolone Acetonide Impairs the Adrenal Function
Information source: HaEmek Medical Center, Israel
Information obtained from ClinicalTrials.gov on November 03, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Secondary Adrenal Insuffisency
Phase: N/A
Status: Recruiting
Sponsored by: HaEmek Medical Center, Israel Official(s) and/or principal investigator(s):
Avraham Ishay, MD, Principal Investigator, Affiliation: Haemek Medical Center , Endocrine Institute
Overall contact:
Avraham Ishay, MD, Phone: 97246495556, Email: ishay_av@clalit.org.il
Summary
The use of intravitreal corticosteroids in the management ocular inflammatory diseases has
recently gained widespread acceptance. The purpose of this study is to determine if the use
of intravitreal triamcinolone is associated with suppression of endogenous cortisol
production, as generally admitted for patients treated with oral or parenteral corticosteroid
therapy.
Clinical Details
Official title: Low Dose (1mcg ) ACTH Stimulation Test for Assessment of the Hypothalamo- Pituitary- Adrenal Axis in Patients Treated With Intravitreal Injection of Triamcinolone Acetonide
Study design: Case-Only, Prospective
Detailed description:
The normalcy of hypothalamic- pituitary- adrenal axis (HPA axis) of enrolled subjects will
will be assessed before intravitreal injection of 4mg of triamcinolone and again after one
day, one week and two weeks. Patients with abnormal HPA axis will be re-tested after four
weeks and later until the HPA axis function return to normal. The HPA axis will be assessed
with low dose (1mcg) intravenous corticotropin(ACTH) stimulation test, in which cortisol
levels will be sampled before , 30 minutes and 60 minutes after 1mcg ACTH IV injection.
Eligibility
Minimum age: 18 Years.
Maximum age: 75 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- patients receiving intravitreous injection of triamcinolone 4mg
Exclusion Criteria:
- patients receiving steroids in any form, except by intravitreous administration
Locations and Contacts
Avraham Ishay, MD, Phone: 97246495556, Email: ishay_av@clalit.org.il
Haemek Medical Center, Afula 18101, Israel; Recruiting
Avraham Ishay, MD, Principal Investigator
Additional Information
Starting date: April 2007
Ending date: January 2008
Last updated: November 18, 2007
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