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Abatacept for SLE Arthritis (IM101-330)

Information source: University of California, Los Angeles
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Systemic Lupus Erythematosus Arthritis

Intervention: abatacept (Drug); Placebo (Drug)

Phase: Phase 1/Phase 2

Status: Not yet recruiting

Sponsored by: University of California, Los Angeles

Official(s) and/or principal investigator(s):
Bevra Hahn, M.D., Principal Investigator, Affiliation: University of California, Los Angeles

Overall contact:
Bevra Hahn, M.D., Phone: 310-825-7991, Email: bhahn@mednet.ucla.edu

Summary

This research trial is for patients who have been diagnosed with systemic lupus erythematosus (SLE) with swollen, tender joints (which is called inflammatory polyarthritis) because of the SLE. The purpose of this clinical research study is to evaluate the safety and effectiveness of treatment with abatacept (Abatacept) 125mg injected subcutaneously (under the skin) weekly for 16 weeks versus placebo injections(a substance with no active ingredients and therefore may have no treatment benefit) in subjects with SLE and inflammatory polyarthritis. The effectiveness will be assessed primarily by the number of swollen, tender joints (called a joint count) at each of study visits. Study Medication Abatacept is approved in the U. S. for treating rheumatoid arthritis by prescription and has not been approved by the U. S. Food and Drug Administration for treating SLE yet. In this study, subjects will receive treatment with either abatacept or placebo once a week for 16 weeks (a total of 16 injections).

Clinical Details

Official title: Efficacy of Abatacept in Inflammatory Polyarthritis of Systemic Lupus Erythematosus (SLE)

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Baseline to 16 week comparison of at least a 20% improvement in Tender and Swollen 28 joint count over the 16 weeks period

Secondary outcome:

Baseline to 16 week comparison of SLEDAI 2K improvement between patients in two study arms

Baseline to 16 week comparison of change in the PGA score between patients in two study arms

Longitudinal changes in CDAI between patients in two study arms

Baseline to 16 week comparison of changes in the synovitis, tenosynovitis and erosions scores measured by ultrasound between patients in two study arms

Baseline to 16 week comparison of changes in the FACIT fatigue score between patients in two study arms

Baseline to 16 week comparison of changes in the SF 36 quality of life score between patients in two study arms

Difference in the number of AEs and SAEs between patients in two study arms

Longitudinal changes in the total number of tender and swollen joints between patients in two study arms

Baseline to 16 week change in peripheral blood T cell compartments between patients in two study arms

Longitudinal change in anti-DNA and total IgG levels as well as Serum complement levels between patients in two study arms

Longitudinal change in serum levels of BAFF between patients in two study arms

Time to response of 20% improvement in joint counts between patients in two study arms

Comparing baseline to 16 week improvement for the total sum score of tender and swollen joints between the two study arms

Comparing the proportion of patients who are able to taper prednisone to <10mg/day by week 16 between the two study arms

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria: 1. Meet at least 4 of the 11 American College of Rheumatology (ACR) 1997 criteria for classification of SLE (see Appendix 1).OR meet the recent classification recommended by SLICC (Appendix 2) 6 2. ≥3 swollen and tender joints on 2 examinations at least 2 weeks apart and no more than 8 weeks apart. 3. SLEDAI2K score ≥4 indicating active disease. 4. Documented positive ANA (≥1: 80) and/or anti-dsDNA during course of SLE. 5. Men and women, at least 18 years of age. Women of childbearing potential must use adequate method(s) of contraception to avoid pregnancy throughout the study and for up to 2 months after last study drug dose. They must have a negative serum or urine pregnancy test prior to the start of study medication. 6. Background therapies allowed: antimalarials (dose constant for ≥ one month before study entry and during 16 weeks of trial), methotrexate (same criteria as for antimalarials), azathioprine (same criteria), mycophenolate (same criteria), leflunomide (same criteria). During the screening period and for up to 6 weeks after randomization, a daily prednisone (or equivalent) regimen of up to 20 mg daily may be initiated to treat the moderate to severe disease activity present at screening. The initial steroid regimen is not required if investigators or patients believe that the risks would outweigh the potential benefits. Patients who do not take any glucocorticoids during the study will be included in the treatment groups and analysis. *Steroids should be tapered to a target dose of no more than 10 mg/day of prednisone (or equivalent) by the end of Week 8 (Day 56). The steroid regimen should be tapered as quickly as safely possible. Prednisone dose requirements higher than 10 mg daily at the 8 week visit will cause the patient to be ruled a non-responder for the abatacept treatment arm. Exclusion Criteria: 1. Subjects with active infection requiring oral or IV antibiotics within one month of first dose of study medication. 2. Subjects with BILAG A in any system outside the musculoskeletal system. 3. Subjects with positive quantiferon Gold test in the absence of treatment for tuberculosis. 4. Subjects with positive tests for active infection with hepatitis B or C during the past 6 months. Any confirmed positive test for HIV at any time prior to entry into this study. 5. Subjects with active glomerulonephritis (>3 g protein/24h and/or active urine sediment). 6. Subjects with active CNS disease. 7. Subjects with any other serious disease that would require immunosuppressive or parenteral anti-microbial therapy outside the study protocol. 8. Inability to self-administer subcutaneous injections, to comply with instructions, or to keep appointments for study visits. 9. Treatment with rituximab within the past 6 months (B cells must be detectable in peripheral blood at onset of treatment with study biologic), belimumab within the past 5 months, cyclophosphamide within the past 3 months. 10. Treatment with any other immunomodulatory biologic or cyclophosphamide during treatment with abatacept is not allowed. 11. Patients requiring >20 mg of prednisone daily. 12. Women who are pregnant or breast feeding. 13. Women of child bearing potential unwilling or unable to use an acceptable method to avoid pregnancy for the entire study period and for up to 2 months after last study drug. 14. Subjects with a history of cancer within the last five years (other than non-melanoma skin cell cancers cured by local resection). 15. Any laboratory test results that, in the opinion of the Investigator, might place the subject at unacceptable risk for participation in this study.

Locations and Contacts

Bevra Hahn, M.D., Phone: 310-825-7991, Email: bhahn@mednet.ucla.edu

UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles, California 90095, United States; Not yet recruiting
Hahn Bevra, M.D., Phone: 310-825-7991, Email: bhahn@mednet.ucla.edu
Jennifer Grossman, M.D., Sub-Investigator
Maureen McMahon, M.D., Sub-Investigator

University of California, San Diego, San Diego, California 92093, United States; Not yet recruiting
Kenneth Kalunian, M.D., Phone: 858-657-7049, Email: kkalunian@ucsd.edu

Additional Information

Starting date: May 2015
Last updated: April 28, 2015

Page last updated: August 23, 2015

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