Does Administration of Etomidate and Propofol of the Anesthetic Induction of Elderly Hypertensive Patient Provide Superior Blood Pressure Stability in Response to Direct Laryngoscopy When Compared to Propofol or Etomidate Alone?

Condition(s) targeted: Hypertension

Intervention: propofol (Drug); Etomidate (Drug); Propofol and Etomidate (Drug)

Phase: Phase 3

Status: Not yet recruiting

Sponsored by: University of Mississippi Medical Center

Official(s) and/or principal investigator(s):
Cynthia A Vaughn, MD, Study Chair, Affiliation: University of Mississippi Medical Center

Overall contact:
Cynthia A Vaughn, MD, Phone: 601-984-5900, Ext: 45903, Email: cvaughn@umc.edu

This study will attempt to show that a combination of drugs, Etomidate and Propofol, provide a more stable blood pressure when used to put elderly hypertensive patients to sleep than either drug used alone.

Official title: Does Administration of Etomidate and Propofol if the Anesthetic Induction of the Elderly Hypertensive Patient Provide Superior Blood Pressure Stability in Response to Direct Laryngosacopy, When Compared to Propofol or Etomidate Alone?

Study design: Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label

Primary outcome: Blood pressure stability during anesthetic induction

Detailed description: Same as above.

Minimum age: 65 Years. Maximum age: 90 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients at least 65 years old, with a history of hypertension.

Exclusion Criteria:

- Patients less than 65 years old or without a history of hypertension.

Cynthia A Vaughn, MD, Phone: 601-984-5900, Ext: 45903, Email: cvaughn@umc.edu

University of Mississippi Medical Center, Jackson, Mississippi 39216, United States

Starting date: January 2011
Last updated: November 24, 2010