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Efficacy and Safety of Electrical Versus Pharmacological Cardioversion in Early Atrial Fibrillation

Information source: Valduce Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Atrial Fibrillation

Intervention: electrical cardioversion (Procedure); propafenone (Drug)

Phase: N/A

Status: Completed

Sponsored by: Valduce Hospital


The optimal strategy to restore sinus rhythm in patients with atrial fibrillation (AF) of less than 48 hours' duration is still controversial. The investigators performed a controlled single-center trial to compare electrical and pharmacological (propafenone) cardioversion to restore the sinus rhythm in selected patients with acute atrial fibrillation.

Clinical Details

Official title: Efficacy and Safety of Electrical Versus Pharmacological Cardioversion in Early Atrial Fibrillation: a Randomized Controlled Trial

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment

Primary outcome: Efficacy of intervention (Electrical and pharmacological cardioversion) in restoring sinus rythm

Secondary outcome:

Number of adverse events related to electrical and pharmacological cardioversion

recurrence of atrial fibrillation


Minimum age: 18 Years. Maximum age: 85 Years. Gender(s): Both.


Inclusion Criteria:

- atrial fibrillation of less than 48 hours' duration.

Exclusion Criteria:

- AF of more than 48 hours'

- hemodynamic instability

- acute onset atrial fibrillation due to acute coronary syndrome

- electrolyte disturbances

- sepsis

- fever

- hypothermia

- untreated hyperthyroidism

- use of antiarrhythmic drugs

- high embolic risk

- unclear duration of symptoms

Locations and Contacts

Emergency Unit - Valduce Hospital, Como 22100, Italy
Additional Information

Starting date: January 2006
Last updated: July 2, 2009

Page last updated: August 23, 2015

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