Multicenter Registry Study With Therapeutic Hypothermia After Cardiac Arrest in Japan

Condition(s) targeted: Cardiac Arrest

Phase: N/A

Status: Recruiting

Sponsored by: National Cardiovascular Center, Japan

Official(s) and/or principal investigator(s):
Hiroshi Nonogi, MD, Principal Investigator, Affiliation: Department of Cardiology, National Cardiovascular Center , Japan

Overall contact:
Hiroshi Nonogi, MD, Phone: +81-6-6833-5004, Ext: 2233, Email: hnonogi@hsp.ncvc.go.jp

Recently, early defibrillation and cardiopulmonary resuscitation (CPR) for sudden onset of cardiac arrest are advancing, however, survival rate is still very low in the world. Furthermore, post-cardiac arrest brain injury is a common cause of morbidity and mortality after successful resuscitation which is urgent issue to be solved. Therapeutic hypothermia is part of a standardized treatment strategy for comatose survivors of cardiac arrest in the metabolic phase usually about 15 minutes after cardiac arrest. However, the evidences of the efficacy of therapeutic hypothermia are still few. The optimal candidates, temperature, the timing of initiation, the therapeutic windows and the rate for rewarming have not been defined clinically and should be established. The purpose of this research is the improvement in the outcomes for patients with coma after resuscitation from out-of-hospital cardiac arrest using therapeutic hypothermia established from the analysis of multicenter registry data.

Official title: Multicenter Registry Study With Therapeutic Hypothermia After Cardiac Arrest in Japan

Study design: Cohort, Other

Primary outcome: Survival and functional outcome (CPC: Cerebral Performance Categories)

Secondary outcome:

Survival and/or functional outcome

Survival and/or functional outcome

Survival and/or functional outcome

Survival and/or functional outcome

Survival or functional outcome

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Adult patients who remained unconscious after resuscitation from out-of-hospital or

inhospital cardiac arrest

- Presented the stable hemodynamics with drug treatments or mechanical supporting

system including IABP or PCPS

Exclusion Criteria:

- Patients with:

- pregnancy

- acute aortic dissection

- pulmonary thromboembolism

- drug poisoning

- poor daily activity

Hiroshi Nonogi, MD, Phone: +81-6-6833-5004, Ext: 2233, Email: hnonogi@hsp.ncvc.go.jp

Hiroshima City Hospital, Hiroshima, Japan; Recruiting
Tastuya Maruhashi, MD, Email: maruchi@joy.ocn.ne.jp
Tatsuya Maruhashi, MD, Principal Investigator

Osaka Police Hospital, Osaka, Japan; Recruiting
Kazunori Kashiwase, MD, Email: kassy@ohp.gr.jp
Kazunori Kashiwase, MD, Principal Investigator

Sumitomo Hospital, Osaka, Japan; Not yet recruiting
Yasuga Yuji, MD, Email: yyasuga@gmail.com
Yuji Yasuga, MD, Principal Investigator

Osaka City General Hospital, Osaka, Japan; Recruiting
Hideki Arimoto, MD, Email: arimoto-circ@umin.ac.jp
Hideki Arimoto, MD, Principal Investigator

Saga University Hospital, Saga, Japan; Recruiting
Yuichi Motomura, MD, Email: d4402@cc.saga-u.ac.jp
Tomokazu Motomura, MD, Principal Investigator

Nihon University Surugadai Hospital, Tokyo, Japan; Recruiting
Ken Nagao, MD, Email: kennagao@med.nihon-u.ac.jp
Ken Nagao, MD, Principal Investigator

Kitazato University Hospital, Tokyo, Japan; Not yet recruiting
Kazui Soma, MD, PhD
Kazui Soma, MD, Principal Investigator

Kokura Memorial Hospital, Kitakyushu, Fukuoka, Japan; Recruiting
Shinichi Shirai, MD, Email: s-sirai@db3.so-net.ne.jp
Shinichi Shirai, MD, Principal Investigator

Sapporo City University Hopistal, Sapporo, Hokaido, Japan; Recruiting
Mamoru Hase, MD, Email: hase@sapmed.ac.jp
Mamoru Hase, MD, Principal Investigator

Kobe City Medical Center Genaral Hospital, Kobe, Hyogo, Japan; Recruiting
Takuro Hayashi, MD, Email: takuro@kcgh.gr.jp
Takuro Hayashi, MD, Principal Investigator

Kagawa University Hospital, Takamatsu, Kagawa, Japan; Not yet recruiting
Yasuhiro Kuroda, MD
Yasuhiro Kuroda, MD, Principal Investigator

Yokohama City University Medical Center, Yokohama, Kanagawa, Japan; Recruiting
Yoshio Tahara, MD, Email: tahara@urahp.yokohama-cu.ac.jp
Yoshio Tahara, MD, Principal Investigator

National Cardiovascular Center, Suita, Osaka 565-8565, Japan; Recruiting
Hiroyuki Yokoyama, MD, Phone: +81-6-6833-5012, Email: hiyokoya@hsp.ncvc.go.jp
Noriaki Kokubu, MD
Hiroyuki Yokoyama, MD, Principal Investigator
Nobuaki Kokubu, MD, Sub-Investigator

Osaka Saiseikai Senri Hospital, Suita, Osaka, Japan; Recruiting
Hirotaka Sawano, MD, Email: hsawano@senri.saiseikai.or.jp
Hirotaka Sawano, MD, Principal Investigator

Osaka Mishima Emergency Critical Care Center, Takatsuki, Osaka, Japan; Recruiting
Hiroshi Hazui, MD, Email: hazui112@osaka-mishima.jp
Hiroshi Hazui, MD, Principal Investigator

Yamaguchi University Hospital, Ube, Yamaguchi, Japan; Recruiting
Shunji Kasaoka, MD, Email: skasa@yamaguchi-u.ac.jp
Shunji Kasaoka, MD, Principal Investigator

Starting date: June 2008
Ending date: March 2010
Last updated: June 11, 2009