Comparison of Blood Pressure Medications on Metabolism
Information source: University of New Mexico
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Diabetes
Intervention: carvedilol (Drug); metoprolol (Drug)
Phase: Phase 4
Status: Active, not recruiting
Sponsored by: University of New Mexico
Summary
The purpose of this study is to determine if there are differences, (benefits) between
carvedilol and metoprolol in the treatment of HTN in patients with type 2 diabetes.
Specifically we will be looking at differences in blood pressure and blood sugar control,
endothelial function, inflammation, oxidative stress and coagulation.
Subjects will be randomized to one of the two beta-blockers and followed for 5 months. Each
subject will undergo 4 inpatient studies where an oral glucose tolerance test will be done,
Inflammatory and oxidative stress markers will be measured. Endothelial function will be
measured using brachial artery ultrasound and laser skin Doppler
Clinical Details
Official title: Carvedilol vs.Metoprolol: A Comparison of Effects on Endothelial Function and Oxidative Stress in Response to Acute Hyperglycemia in Patients With Type 2 Diabetes and Hypertension
Study design: Diagnostic, Randomized, Double Blind (Subject, Investigator, Outcomes Assessor), Active Control, Parallel Assignment, Efficacy Study
Primary outcome: change in endothelial function
Eligibility
Minimum age: 45 Years.
Maximum age: 85 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- not enrolling
Exclusion Criteria:
- not enrolling
Locations and Contacts
UNMHSC, Albquerque, New Mexico 87131, United States
Additional Information
Starting date: January 2004
Ending date: July 2008
Last updated: March 24, 2008
|
