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Relationship Between Erythropoietin Administration and Stress Responses in Trauma Patients

Information source: Tehran University of Medical Sciences
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Multiple Trauma

Intervention: erythropoietin (Drug); placebo (Drug)

Phase: Phase 2

Status: Recruiting

Sponsored by: Tehran University of Medical Sciences

Official(s) and/or principal investigator(s):
MOJTABA MOJTAHEDZADE, Study Chair, Affiliation: TUMS
MOSTAFA MOHAMMADY, Principal Investigator, Affiliation: TUMS
MOJTABA MOJTAHED, Study Director, Affiliation: TUMS

Overall contact:
mojtaba mojtahedzade, Phone: 0982166701041, Email: Mojtahed@sina.tums.ac.ir

Summary

The purpose of this study is to determine whether Erythropoietin decrease stress responses and inflammation in trauma patient.

Clinical Details

Official title: Relationship Between Clinical Recovery and Oxidative Stress and Inflammation Following Usage of Erythropoietin in Admitted Traumatic Patient In Intensive Care Unit

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: apachi 2 saps 30 days mortality

Secondary outcome: 30 days mortality

Detailed description: Transfusion of blood products has many disadvantages. Erythropoietin is used to increase red blood cells production and decrease such disadvantages. In some studies anti inflammatory effects is shown for Erythropoietin. One of the most problems in the intensive care unit is stress response. we are going to evaluate effects of erythropoietin on oxidative stress and inflammation in trauma patient in intensive care unit.

Eligibility

Minimum age: 40 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- All multiple trauma patients>16 years with informed consent

Exclusion Criteria:

- Hypertension

- Allergy

- Erythroid leukemia

- Pregnancy and breast feeding

- Pre operative patient

- Severe cardiovascular and cerebrovascular diseases

- Thromboembolic disorders

Locations and Contacts

mojtaba mojtahedzade, Phone: 0982166701041, Email: Mojtahed@sina.tums.ac.ir

Sina Hospital, Tehran, Iran, Islamic Republic of; Recruiting
MOJTAHEDZADE, Phone: 098216701041-9
MOHAMMADY, Phone: 0989126053454
MOSTAFA MOHAMMADY, Sub-Investigator
MOJTABA MOJTAHEDZADE, Principal Investigator
Additional Information

Starting date: July 2007
Last updated: November 17, 2010

Page last updated: August 23, 2015

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