Effect of Creatine and L-Arginine on Endothelial Function
Information source: Boston University
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Coronary Artery Disease
Intervention: Creatine (Dietary Supplement); L-arginine and creatine (Dietary Supplement); l-arginine (Dietary Supplement); placebo, double (Dietary Supplement)
Phase: N/A
Status: Completed
Sponsored by: Boston University Official(s) and/or principal investigator(s):
Joseph A Vita, MD, Principal Investigator, Affiliation: Boston Medical Center
Summary
The study is a double blind 2x2 factorial study. Patients with coronary disease will be
randomly be assigned to L-arginine (9 g/day), creatine 21 g/d, both, or neither dietary
supplement. The function of the endothelium will be tested using ultrasound before and after
each treatment. These studies will help us understand why the endothelium is abnormal in
patients with coronary artery disease and how L-arginine is acting on endothelial function.
Clinical Details
Official title: Effect of Creatine and L-Arginine on Endothelial Function in Patients With Coronary Artery Disease
Study design: Basic Science, Randomized, Double Blind (Subject, Investigator, Outcomes Assessor), Placebo Control, Factorial Assignment
Primary outcome: Brachial artery flow-mediated dilation
Secondary outcome: serum arginine, creatine, creatinine, homocysteine
Eligibility
Minimum age: 18 Years.
Maximum age: 80 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Coronary artery disease
Exclusion Criteria:
- Pregnancy
- Creatine use within one month of study
- L-arginine use within one month of study
- Change in dose or initiation of lipid lowering therapy, aspirin therapy, or
angiotensin converting enzyme therapy within one month of study
Locations and Contacts
Additional Information
Starting date: August 2002
Ending date: December 2005
Last updated: October 30, 2007
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