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Skin Prick Tests With AllerT in Subjects Allergic to Birch Pollen

Information source: Anergis
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Allergic Rhinitis

Intervention: placebo (Drug); Histamine (Drug); AllerT1 (Drug); AllerT2 (Drug); AllerT3 (Drug); AllerT4 (Drug); AllerT5 (Drug); mix of AllerT1-T2-T3 (Drug); mix of AllerT4-T5 (Drug)

Phase: Phase 1

Status: Completed

Sponsored by: Anergis

Official(s) and/or principal investigator(s):
Francois Spertini, MD, Principal Investigator, Affiliation: Centre Hospitalier Universitaire Vaudois

Summary

Assessment of skin reactivity by skin prick tests to synthetic peptides derived from the major birch allergen bet v 1, in subjects allergic to birch pollen.

Clinical Details

Official title: Détermination de la réactivité cutanée de Volontaires Allergiques au Pollen de Bouleau Contre Des Peptides dérivés de Bet v 1

Study design: Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Screening

Primary outcome: skin prick test reactivity

Detailed description:

The study tested - all by skin tests - in the same group of 20 trial subjects, one positive

control (histamine solution), one negative control (placebo saline) and five experimental peptides called T1, T2, T3, T4 and T5. Results of the skin prick tests were scored as negative (no reaction) or positive (wheal diameter > 4 mm with erythema)

Eligibility

Minimum age: 18 Years. Maximum age: 45 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- history of allergy symptoms during previous birch pollen season

- positive skin prick test to birch pollen extract

Exclusion Criteria:

- pregnancy

- uncontrolled asthma

- other significant clinical conditions or immune disorders

- subjects taking antihistamines or drugs with antihistamine activity

Locations and Contacts

Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Additional Information

Starting date: February 2008
Last updated: October 31, 2012

Page last updated: August 23, 2015

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