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The Effect of Intravenous Lidocaine on Allodynia

Information source: University of Alabama at Birmingham
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Pain

Intervention: lidocaine (Drug)

Phase: N/A

Status: Active, not recruiting

Sponsored by: University of Alabama at Birmingham

Official(s) and/or principal investigator(s):
Michael Froelich, MD, MS, Principal Investigator, Affiliation: University of Alabama at Birmingham


The purpose of this study is to study if lidocaine, given intravenously, reduces pain.

Clinical Details

Official title: The Effect of Intravenous Lidocaine on Allodynia (Carl Koller Grant)

Study design: Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Pain intensity

Detailed description: Clinicians use lidocaine intravenously in a fashion that suggests that it might have analgesic effects. Therefore, we test the hypothesis that lidocaine reduces pain intensity in response to experimental pain.


Minimum age: 19 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Chronic Regional Pain Syndrome diagnostic criteria by the Work Safe BC. vi

Exclusion Criteria:

- History of Substance abuse

- Other Medications: CRPS patients are expected to be treated for chronic pain, whether

the current treatment regimen interferes with sensory motor testing will be determined on a case by case basis.

- Coronary Artery Disease (CAD): unstable

- Congestive Heart Failure (CHF): unstable

- Heart Arrhythmia: symptomatic

- Chronic Obstructive Pulmonary Disease (COPD)

- Lidocaine Allergy

- Diagnostic and Statistical Manual of Mental Disorders (Rev IV): Axis I: Common Axis I

disorders include depression, anxiety disorders, bipolar disorder, ADHD, and schizophrenia. Axis II: borderline personality disorder, schizotypal personality disorder, antisocial personality disorder, and mild mental retardation.

- Presence of Contraindications for MRI

- Presence of electronically, magnetically, and mechanically activated implants

- Electronically, magnetically, and mechanically activated implants

- Ferromagnetic or electronically operated active devices like automatic cardioverter


- Cardiac pacemakers

- Metallic splinters in the eye

- Ferromagnetic haemostatic clips in the central nervous system (CNS)

- Claustrophobia

- Pregnancy

Locations and Contacts

University of Alabama at Birmingham, Birmingham, Alabama 35249, United States
Additional Information

Starting date: December 2008
Last updated: August 4, 2015

Page last updated: August 23, 2015

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