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Food Study of Glimepiride Tablets 1 mg to Amaryl® Tablets 1 mg

Information source: Mylan Pharmaceuticals
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Healthy

Intervention: Glimepiride Tablets 1 mg (Drug); Amaryl® Tablets 1 mg (Drug)

Phase: Phase 1

Status: Completed

Sponsored by: Mylan Pharmaceuticals

Official(s) and/or principal investigator(s):
James D Carlson, Pharm. D., Principal Investigator, Affiliation: PRACS Institute Ltd.

Summary

The objective of this study was to investigate the bioequivalence of Mylan's glimepiride 1 mg tablets to Aventis Amaryl 1 mg tablets following a single, oral 1 mg (1 x 1 mg) dose administered under fed conditions.

Clinical Details

Official title: Single-Dose Food In Vivo Bioequivalence Study of Glimepiride Tablets (1 mg; Mylan) to Amaryl Tablets (1 mg; Aventis) in Healthy Volunteers

Study design: Basic Science, Randomized, Open Label, Crossover Assignment, Bio-equivalence Study

Primary outcome: Bioequivalence

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

1. Age: 18 years and older.

2. Sex: Male and/or non-pregnant, non-lactating female. a. Women of childbearing potential must have a negative serum (Beta HCG) pregnancy test performed within 14 days prior to the start of the study and on the evening prior to each dose administration. If dosing is scheduled on Sunday or Monday, the HCG pregnancy test should be given within 48 hours prior to dosing of each study period. An additional serum (Beta HCG) pregnancy test will be performed upon completion of the study. b. Women of childbearing potential must practice abstinence or be using an acceptable form of contraception throughout the duration of the study. No hormonal contraceptives or hormonal replacement therapies are permitted in this study. Acceptable forms of contraception include the following: 1) intrauterine device in place for at least 3 months prior to the start of the study and remaining in place during the study period, or 2) barrier methods containing or used in conjunction with a spermicidal agent, or 3) surgical sterilization c. Women will not be considered of childbearing potential if one of the following is reported and documented on the medical history: 1) postmenopausal with an absence of menses for at least one (1) year, or 2) bilateral oophorectomy with or without a hysterectomy and an absence of bleeding for at least 6 months, or 3) total hysterectomy d. During the course of the

study, from study screen until study exit - including the washout period, all males

and women of childbearing potential must use a spermicide containing barrier method of contraception in addition to their current contraceptive method. This advice should be documented in the informed consent form.

3. Weight: At least 60 kg (132 lbs) for men and 48 kg (106 lbs) for women and all subjects within 15% of Ideal Body Weight (IBW), as referenced by the Table of "Desirable Weights of Adults" Metropolitan Life Insurance Company, 1999 (See Part II ADMINISTRATIVE ASPECTS OF BIOEQUIVALENCE PROTOCOLS).

4. All subjects should be judged normal and healthy during a pre-study medical evaluation (physical examination, laboratory evaluation, Hepatitis B and Hepatitis C tests, HIV test, 12-lead ECG, and urine drug screen including amphetamine, barbiturates, benzodiazepines, cannabinoid, cocaine, opiate screen, phencyclidine, and methadone) performed within 14 days of the initial dose of study medication.

Exclusion Criteria:

1. Institutionalized subjects will not be used.

2. Social Habits: a. Use of any tobacco products within 1 year of the start of the study. b. Ingestion of any alcoholic, caffeine- or xanthine-containing food or beverage within the 48 hours prior to the initial dose of study medication. c. Ingestion of any vitamins or herbal products within the 7 days prior to the initial dose of the study medication. d. Any recent, significant change in dietary or exercise habits. e.  A positive test for any drug included in the urine drug screen. f.  History of drug and/or alcohol abuse.

3. Medications: a. Use of any prescription and/or over-the-counter (OTC) medications which include but are not limited to aspirin, ibuprofen, and NSAIDs within 14 days prior to the initial dose of study medication. b. Use of any hormonal contraceptives or hormone replacement therapy within 3 months prior to study medication dosing. c. Use of any medication known to alter hepatic enzyme activity within 28 days prior to the initial dose of study medication.

4. Diseases: a. History of any significant cardiovascular, hepatic, renal, pulmonary, hematologic, gastrointestinal, endocrine, immunologic, dermatologic, neurologic disease. b. Acute illness at the time of either the pre-study medical evaluation or dosing. c. A positive HIV, hepatitis B, or hepatitis C test.

5. Abnormal and clinically significant laboratory test results: a. Clinically significant deviation from the Guide to Clinically Relevant Abnormalities (See Part II ADMINISTRATIVE ASPECTS OF BIOEQUIVALENCE PROTOCOLS). b. Abnormal and clinically relevant ECG tracing.

6. Donation or loss of a significant volume of blood or plasma (> 450 mL) within 28 days prior to the initial dose of study medication.

7. Subjects who have received an investigational drug within 30 days prior to the initial dose of study medication.

8. Allergy or hypersensitivity to glimepiride or any other drugs of the sulfonylurea class.

9. History of difficulties in swallowing, or any gastrointestinal disease which could affect the drug absorption.

10. Subjects who have serum creatinine levels outside the normal range.

Locations and Contacts

PRACS Institute, Ltd., Fargo, North Dakota 58104, United States
Additional Information

Mylan Pharmaceuticals Inc. - Clinical Trial Results

Daily Med - posting of most recent submitted labelling to the Food and Drug Administration (FDA) and currently in use

Recalls, Market Withdrawals and Safety Alerts

FDA Enforcement Report Index

Medwatch, FDA Safety Information and Adverse Event Reporting Program

Starting date: November 2004
Ending date: December 2004
Last updated: March 31, 2008

Page last updated: June 20, 2008

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