Neuropeptides in the Humane Intra- og Extracerebral Circulation.
Information source: Danish Headache Center
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Healthy; Migraine
Intervention: sumatriptan (Drug)
Phase: N/A
Status: Completed
Sponsored by: Danish Headache Center Official(s) and/or principal investigator(s):
Jakob Møller Hansen, MD, Principal Investigator, Affiliation: Danish Headache Center
Summary
The study aim at examining whether Sumatriptan changes the plasma values of the neuropeptides
vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP) and pituitary
adenylate cyclase activating peptide (PACAP) and the prostanoids 6-keto-PGF1α, and PGE2, PGD2
og PGF2α.
Clinical Details
Official title: Neuropeptides in the Humane Intra- og Extracerebral Circulation - in Relation to Sumatriptan in Healthy Volunteers.
Study design: Other, Non-Randomized, Single Blind, Uncontrolled, Single Group Assignment, Pharmacokinetics Study
Primary outcome: Blood concentration of vasoactive intestinal polypeptide (VIP),calcitonin gene-related protein (CGRP), pituitary adenylate cyclase activating peptide (PACAP,) and the prostanoids 6-keto-PGF1α, PGE2, PGD2 and PGF2α, sampled from different venous catheters.
Detailed description:
The study is meant to give a better understanding of the basic mechanisms behind migraine,
and a better understanding of the effects of sumatriptan on the trigemino vascular system.
The endpoints are changes in the plasma values of the neuropeptides vasoactive intestinal
polypeptide (VIP), calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase
activating peptide (PACAP) and the prostanoids 6-keto-PGF1α, and PGE2, PGD2 og PGF2α.
Eligibility
Minimum age: 18 Years.
Maximum age: 50 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- healthy volunteers
- 18-50 years,
- 50-100 kg.
- Fertile women must use birth control.
Exclusion Criteria:
- All primary types of headache
- Daily intake of medicine except birth control
- Pregnancy
- Hypertension
- Hypotension
- other chronic disease
Locations and Contacts
Danish Headache Center, Glostrup, Copenhagen, Copenhagen 2600, Denmark
Additional Information
The homepage of the Danish Headache Center
Starting date: January 2007
Ending date: April 2007
Last updated: May 13, 2008
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