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Effects of Cisatracurium on Sccinylcholine-induced Fasciculations

Information source: Yangzhou No.1 People's Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Fasciculations

Intervention: Cisatracurium (Drug)

Phase: Phase 3

Status: Not yet recruiting

Sponsored by: Zhuan Zhang

Summary

To investigate the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations.

Clinical Details

Official title: Effects of Pretreatment With Different Doses of Cisatracurium on Succinylcholine-induced Fasciculations

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Primary outcome: Presence of fasciculations

Secondary outcome:

Side effects of the pretreatment of cisatracurium

The time to maximal depression of twitch

The extent to maximal depression of twitch

The grades of endotracheal intubation

The changes of serum potassium

Myalgia at 24 hours postoperatively

Detailed description: Ninety patients scheduled for laparoscopic cholecystectomies were equally randomized into three groups to receive pretreatment of 0. 005, 0. 01, and 0. 02 mg/kg cisatracurium, respectively. General anesthesia was induced 3. 5 min later, train of four stimulation was monitored 4. 5 min later, succinylcholine 1. 5 mg/kg was injected 5 min later, and endotracheal intubation was implemented 6. 5 min later. The side effects of cisatracurium, intensity of fasciculations, intubating conditions, time and extent to maximal depression of twitch and time for its recovery to 20% of control value, severity of myalgia at 24 h postoperatively, serum potassium before cisatracurium pretreatments, at intubating time, and 5 min after intubation were recorded.

Eligibility

Minimum age: 20 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- American Standards Association (ASA) physical status I or II patients scheduled for

elective laparoscopic cholecystectomies with tracheal intubation requiring general anesthesia;

- 20 - 65 years old;

- Without acid-base imbalance and electrolyte disturbance;

- With normal hepatic and renal function.

Exclusion Criteria:

- Patients with the contraindications associated with succinylcholine or cisatracurium;

- Patients taking drugs known to alter the action of neuromuscular blockers;

- Patients with a body mass index exceeding 30

Locations and Contacts

Additional Information

Starting date: July 2015
Last updated: July 16, 2015

Page last updated: August 23, 2015

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