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Comparison of Vascular Function in Emergency Service Professionals

Information source: University of Edinburgh
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Vascular Function; Atherothrombosis

Intervention: Forearm Vascular Study (Procedure); Badimon Chamber (Procedure)

Phase: N/A

Status: Recruiting

Sponsored by: University of Edinburgh

Official(s) and/or principal investigator(s):
David E Newby, MD PhD, Study Chair, Affiliation: University of Edinburgh
Nicholas L Mills, MBChB PhD, Study Director, Affiliation: University of Edinburgh
Amanda L Hunter, MBChB, Principal Investigator, Affiliation: University of Edinburgh

Overall contact:
Amanda L Hunter, MBChB, Phone: +441312426437, Email: amanda.hunter@ed.ac.uk

Summary

Emergency Service Professionals have an increased risk of death from heart attacks when compared to the general public. All the emergency professions share similar responsibilities such as emergency call-outs and shift work. Heart disease is the commonest cause of on-duty death amongst fire-fighters accounting for 45% and compared with 22% in police officers and 15% in the general population. The unique risk to fire-fighters is likely to reflect a combination of factors including extreme physical exertion, mental stress, heat and pollutant exposure. In this study the investigators will assess healthy career fire-fighters and age-matched healthy police officer control subjects following a sedentary period. The investigators will take blood samples to measure platelet activity (platelets are the particles in blood that help blood clot) and will examine how blood clots outside of the body. The investigators will then perform studies placing small needles in the arm to assess how the blood vessels respond following these duties. The investigators hypothesise that fire-fighters do not have pre-existing impairment of heart, blood or blood vessel function as a cumulative effect of their occupation, but rather these are acute and transitory effects following distinct fire-fighter duties. We therefore expect similar results in both occupational groups.

Clinical Details

Official title: Comparison of Vascular Function in Emergency Service Professionals

Study design: Observational Model: Case Control, Time Perspective: Prospective

Primary outcome: Forearm blood flow measured by venous occlusion plethysmography in response to infused vasodilators

Secondary outcome:

Ex-vivo thrombus formation using the Badimon chamber

Plasma t-PA and PAI concentrations following infusion of bradykinin

Eligibility

Minimum age: 18 Years. Maximum age: 60 Years. Gender(s): Male.

Criteria:

Inclusion Criteria:

- Non-smoking healthy firefighters

Exclusion Criteria:

- Current smoker

- History of lung or ischaemic heart disease

- Malignant arrhythmia

- Systolic blood pressure >190mmHg or <100mmHg

- Renal or hepatic dysfunction

- Previous history of blood dyscrasia

- Unable to tolerate the supine position

- Blood donation within the last 3 months

- Recent respiratory tract infection within the past 4 weeks

- Routine medication including aspirin and NSAIDs

Locations and Contacts

Amanda L Hunter, MBChB, Phone: +441312426437, Email: amanda.hunter@ed.ac.uk

Royal Infirmary of Edinburgh Clinical Research Facility, Edinburgh EH16 4SA, United Kingdom; Recruiting
Amanda L Hunter, MBChB, Phone: +441312426437, Email: amanda.hunter@ed.ac.uk
Nicholas L Mills, MBChB PhD, Phone: +441312426437, Email: nick.mills@ed.ac.uk
Amanda L Hunter, MBChB, Principal Investigator
Additional Information

Starting date: April 2012
Last updated: March 14, 2013

Page last updated: August 23, 2015

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