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The Use of Capsaicin Challenge for Diagnosis, Monitoring and Follow-up of Chronic Cough.

Information source: Tel-Aviv Sourasky Medical Center
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Chronic Cough

Intervention: capsaicin challenge (Other)

Phase: N/A

Status: Not yet recruiting

Sponsored by: Tel-Aviv Sourasky Medical Center

Summary

The purpose of this study is to determine whether the capsaicin challenge can improve the diagnosis, treatment, monitoring and follow-up in patients with chronic cough.

Clinical Details

Official title: The Use of Capsaicin Challenge for Diagnosis, Monitoring and Follow-up of Chronic Cough.

Study design: Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Primary outcome: cough reflex hypersensitivity

Detailed description: Capsaicin is administrated in incremental concentrations with two inhalations of normal saline solution. Patients are instructed to exhale to functional residual capacity and than to inhale through the mouthpiece for 1 second (single breath inhalation). The number of coughs in the first 10 seconds after each inhalation is counted. C2; the concentration of which the patient responded by 2 coughs, C5;the concentration of which the patient responded by 5 coughs. The challenge ends at C5.

Eligibility

Minimum age: N/A. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients with persisting cough for more than 3 months, without known respiratory or

lung diseases Exclusion Criteria:

- Diagnosis of respiratory or lung diseases of any kind

Locations and Contacts

Additional Information

Starting date: March 2013
Last updated: March 7, 2013

Page last updated: August 20, 2015

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