Effect of ACE-Inhibitors on Aortic Stiffness in Elderly Patients With Chronic Kidney Disease

Condition(s) targeted: Cardiovascular Disease; Chronic Kidney Disease

Intervention: angiotensin converting enzyme inhibitor (Drug); lisinopril (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: University of Wisconsin, Madison

Official(s) and/or principal investigator(s):
Lisa M Nanovic, DO, Principal Investigator, Affiliation: University of Wisconsin-Madison School of Medicine and Public Health

Overall contact:
Lisa M Nanovic, DO, Phone: 608-270-5656, Email: ln3@medicine.wisc.edu

The goal of this proposal is to investigate the potential for ACE-inhibitors (ACE-I)(drugs primarily used to treat hypertension or congestive heart failure) to prevent or delay cardiovascular disease (CVD) in older adults with chronic kidney disease (CKD) by examining their impact on aortic stiffness in people with stage 3 CKD in a randomized, controlled study.

Official title: Effect of ACE-Inhibitors on Aortic Stiffness in Elderly Patients With Chronic Kidney Disease

Study design: Treatment, Randomized, Double Blind (Subject, Investigator), Parallel Assignment, Efficacy Study

Primary outcome: There may be a statistical correlation between eGFR(estimated glomerular function) and PWV (pulse wave velocity) in patients with CKD, the addition of an ACE inhibitor will decrease PWV in all groups, but to a greater extent in patients wil CKD.

Detailed description: Our study will be the first to examine whether aortic stiffness is increased in elderly patients with CKD compared to their age-matched healthy controls and further examine whether ACE-I may delay the progression of aortic stiffness in elderly CKD patients. If ACE-I therapy appears beneficial in preventing or delaying arterial stiffening in elderly patients with CKD, our work has important implications for improving the overall health of this population.

Minimum age: 60 Years. Maximum age: 89 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Age > 60 years

- BP 120/80 or higher *(bps will be checked weekly first 4 weeks to ensure < 130/80

- IF bp remains > 130/80 we will administer other bp meds per JNC VII guidelines)

- CKD stage 3 (GFR 30 - 59 ml/min) for CKD group; no CKD for control group

Exclusion Criteria:

- Known significant CVD (history of MI, recurrent stroke, or NYHA class III or

greater).

- Serum potassium > 5. 2 meq/L

- Known allergy or hypersensitivity to ACE inhibitor or ARB

- Female of childbearing age not practicing contraception

- Current treatment with an ACE-I or ARB (Note: can participate if on ACE-I after 6

week washout period)

- History of ACE-I induced angioedema

- History of angioedema, hereditary or idiopathic

- Persons lacking consent capacity

- 500 mg/dL proteinuria on 2 consecutive spot urine protein/creat ratios

Lisa M Nanovic, DO, Phone: 608-270-5656, Email: ln3@medicine.wisc.edu

University of Wisconsin-Madison Hospitals and Clinics, Madison, Wisconsin 53792, United States; Recruiting
Lisa M Nanovic, DO, Phone: 608-270-5656, Email: ln3@medicine.wisc.edu
Lynn M Jacobson, BS, Phone: 608-265-5489, Email: lmj@medicine.wisc.edu
Lisa M Nanovic, DO, Principal Investigator

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Starting date: March 2009
Ending date: March 2012
Last updated: April 1, 2009