Age-Dependent Memory Benefits From Pharmacologically Enhanced Naps?
Information source: University of California, San Diego
Information obtained from ClinicalTrials.gov on October 19, 2009
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Older Adults
Intervention: Sodium Oxybate (Drug); Zolpidem (Drug); placebo (Drug)
Phase: N/A
Status: Recruiting
Sponsored by: University of California, San Diego Overall contact:
Jen Kanady, BA, Phone: 858-642-3192, Email: jkanady@vapop.ucsd.edu
Summary
The purpose of this study is to investigate whether
1. pharmacologically enhanced naps will show increases in specific sleep stages
2. whether these sleep stages will produces specific increases on memory tests
3. whether older adults will benefit more than young adults from increased SWS or Stage 2
on subsequent declarative and motor memory tests.
Clinical Details
Study design: N/A
Eligibility
Minimum age: 60 Years.
Maximum age: 75 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- English-speaking individuals, half men and half women, and between the ages of 60 and
75 years will be recruited. No ethnic group will be specifically excluded from study.
All participants will be recruited from general San Diego Community. An education
requirement of at least 12 years completed will be imposed, as education may affect
performance on the cognitive task.
Exclusion Criteria:
- Not having a regular sleep-wake schedule (defined as not meeting criteria listed
above and/or a Horne-Ostberg Morningness-Eveningness Questionnaire score not between
31-69)
- Having a sleep disorder (reported or detected on the questionnaires)
- Any personal or immediate family (i. e., first degree relative) history of diagnosed
significant psychopathology
- Personal history of head injury with loss of consciousness greater than 15 minutes or
seizures
- History of substance dependence
- Current use of any psychotropic medications
- Any cardiac, respiratory or other medical condition which may affect cerebral
metabolism
- Given the nature of the stimulus and its presentation, anyone with non-correctable
vision and audition impairments will also be excluded.
Locations and Contacts
Jen Kanady, BA, Phone: 858-642-3192, Email: jkanady@vapop.ucsd.edu
Laboratory for Sleep and Behavioral Neuroscience, La Jolla, California 92093, United States; Recruiting
Jen Kanady, BA, Phone: 858-642-3192, Email: jkanady@vapop.ucsd.edu
Additional Information
Starting date: October 2008
Last updated: October 15, 2008
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