Postpartum Thyroid Measures and Mood
Information source: Oklahoma State University Center for Health Sciences
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Postpartum Depression
Phase: N/A
Status: Completed
Sponsored by: Oklahoma State University Center for Health Sciences Official(s) and/or principal investigator(s):
Gary H. Watson, PhD, Study Director, Affiliation: Philadelphia College of Osteopathic Medicine Georgia Campus
Summary
Women with abnormal serum thyroid antibody levels or abnormal TSH and/or T4 values are more
likely than their normal counterparts to have higher scores on a common postpartum
depression screening test.
Clinical Details
Official title: Postpartum Thyroid Measures and Mood
Study design: Observational Model: Cohort, Time Perspective: Prospective
Primary outcome: Numerical score on the Edinburgh Postnatal Depression Scale
Detailed description:
This small pilot study was an attempt to corroborate a relationship between quantified mood
and thyroid measures, using the numerical scores obtained from a common depression screen,
the Edinburgh Postnatal Depression Scale (EPDS), as a continuum. Mood scores were compared
with presence of thyroid autoantibodies and plasma concentrations of free T4 and TSH.
Eligibility
Minimum age: 18 Years.
Maximum age: 50 Years.
Gender(s): Female.
Criteria:
Inclusion Criteria:
- Over 18 years of age
- In third trimester of pregnancy when recruited
- Negative for the following drugs detected by a urine drug screen:
- Amphetamines
- Barbiturates
- Benzodiazepines
- Cocaine
- Opiates
- Phencyclidine metabolites (PCP), and tricyclic antidepressants
- Vaginal delivery
- Screened negative for major depressive disorder on the Edinburgh Postnatal
Depression Scale (EPDS) at her prenatal enrollment in the study
- Receiving a score of 12 or lower out of a possible 30
Exclusion Criteria:
- Under age 18
- Positive for any of the following drugs:
- Amphetamines
- Barbiturates
- Benzodiazepines
- Cocaine
- Opiates
- Phencyclidine metabolites (PCP), and tricyclic antidepressants
- Cesarean delivery
- EPDS score over 12 at prenatal screening test
Locations and Contacts
Oklahoma State University Center for Health Sciences Houston Park Obstetrics Clinic, Tulsa, Oklahoma 74107, United States
Additional Information
Starting date: January 2000
Last updated: January 26, 2010
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