Laryngeal Injuries After Anesthesia Induction With Sevoflurane and After Anesthesia Induction With Rocuronium

Condition(s) targeted: Laryngeal Injuries

Intervention: Sevoflurane (Drug); Rocuronium (Drug)

Phase: N/A

Status: Completed

Sponsored by: University of Rostock

Anesthesia induction with sevoflurane is not associated with an increased incidence or severity of laryngeal injuries compared with an anesthesia induction with a muscle relaxant.

Official title: Laryngeal Injuries After Anesthesia Induction With Sevoflurane and After Anesthesia Induction With Rocuronium. A Randomized, Prospective, Controlled Trial

Study design: Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Primary outcome: incidence of vocal cord injuries

Secondary outcome:

incidence of hoarseness

incidence of soar throat

Minimum age: 18 Years. Maximum age: 80 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- ear-nose-throat surgery

- orotracheal intubation for surgery of the ear

Exclusion Criteria:

- obesity

- allergy against the study drugs

- patients with a known or suspected difficult airway (Mallampati score 3 or 4 and a

mouth opening < 3. 5 cm).

- all patients were examined by stroboscopy one day before surgery and were excluded

from the study when preexisting pathologies of the vocal cords were found

University of Rostock, Rostock, Mecklenburg/Vorpommern 18057, Germany

Starting date: April 2012
Last updated: February 13, 2013