DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Laryngeal Injuries After Anesthesia Induction With Sevoflurane and After Anesthesia Induction With Rocuronium

Information source: University of Rostock
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Laryngeal Injuries

Intervention: Sevoflurane (Drug); Rocuronium (Drug)

Phase: N/A

Status: Completed

Sponsored by: University of Rostock


Anesthesia induction with sevoflurane is not associated with an increased incidence or severity of laryngeal injuries compared with an anesthesia induction with a muscle relaxant.

Clinical Details

Official title: Laryngeal Injuries After Anesthesia Induction With Sevoflurane and After Anesthesia Induction With Rocuronium. A Randomized, Prospective, Controlled Trial

Study design: Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Primary outcome: incidence of vocal cord injuries

Secondary outcome:

incidence of hoarseness

incidence of soar throat


Minimum age: 18 Years. Maximum age: 80 Years. Gender(s): Both.


Inclusion Criteria:

- ear-nose-throat surgery

- orotracheal intubation for surgery of the ear

Exclusion Criteria:

- obesity

- allergy against the study drugs

- patients with a known or suspected difficult airway (Mallampati score 3 or 4 and a

mouth opening < 3. 5 cm).

- all patients were examined by stroboscopy one day before surgery and were excluded

from the study when preexisting pathologies of the vocal cords were found

Locations and Contacts

University of Rostock, Rostock, Mecklenburg/Vorpommern 18057, Germany
Additional Information

Starting date: April 2012
Last updated: February 13, 2013

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017