Effect of Proton Pump Inhibitor on Gastric Emptying and Satiety Function in Patients With Functional Dyspepsia (BreathID PPI Study)

Condition(s) targeted: Functional Dyspepsia

Intervention: Esomeprazole (Drug); Placebo (Drug)

Phase: Phase 4

Status: Not yet recruiting

Sponsored by: Chinese University of Hong Kong

Official(s) and/or principal investigator(s):
Justin C.Y. Wu, MBChB(CUHK), Principal Investigator, Affiliation: Chinese University of Hong Kong

Overall contact:
Justin C.Y. Wu, MBChB(CUHK), Phone: (852) 2632-3593, Email: justinwu@cuhk.edu.hk

Functional dyspepsia is one of the commonest digestive disorders. The pathophysiology of functional dyspepsia is uncertain. Proton pump inhibitor (PPI) has been recommended as the first line treatment for functional dyspepsia. However, the mechanism of symptom relief is unclear. Most of the previous studies were performed on healthy volunteers who received only a very short course of PPI. The correlation between symptom and gastric emptying is lacking in these studies.

Demographic data and anthropometric measurements will be obtained for baseline assessment. Patients are required to complete FGI Screening Questionnaire, Functional dyspepsia symptom questionnaire, gastroesophageal reflux disease (GERD) symptom questionnaire and irritable bowel syndrome (IBS) symptom questionnaire to have a thorough assessment of their GI symptoms. (1) Satiety test and ghrelin profile, and (2)gastric emptying test with BreathID will be arranged as two individual visits. For test details, please refer to the submitted Protocol (Version 1. 0, 14/05/2009).

After baseline investigations, patients will be randomly assigned to either Pantoprazole 40 mg daily or identical looking placebo for 8 weeks. The patients will report their individual dyspeptic symptoms on weekly basis using a self-administered symptom questionnaire.

Satiety test and ghrelin profile, gastric emptying study will be repeated at the end of 8-week treatment.

Hypothesis: Long-term PPI relieves dyspeptic symptom through acceleration of gastric emptying rate.

Official title: Effect of Proton Pump Inhibitor on Gastric Emptying and Satiety Function in Patients With Functional Dyspepsia

Study design: Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator), Placebo Control, Parallel Assignment, Efficacy Study

Primary outcome: gastric emptying rate as measured by BreathID:Area-under-curve (AUC) values at different time points and half-emptying time (t1/2) after 8 weeks of treatment will be used as measures for gastric emptying rate

Secondary outcome:

calorie intake in satiety test

rate of adequate relief using global symptom assessment

symptom scores

Detailed description: Background

Functional dyspepsia is one of the commonest digestive disorders. It is a functional gastrointestinal disorder which is characterized by chronic recurrent epigastric symptoms such as pain, burning and a variety of postprandial symptoms with absence of demonstrable organic pathology identified on investigations. It has been reported that functional dyspepsia affects 10-30% of adult population.(1)

The pathophysiology of functional dyspepsia is uncertain. It is thought to be a heterogeneous disorder. Various factors have been implicated in the pathophysiology of functional dyspepsia. It has been reported that delayed gastric emptying, impaired proximal gastric accommodation, visceral hypersensitivity and Helicobacter pylori gastritis play a role in development of functional dyspepsia. However, the correlation between these physiological abnormalities and symptomatology of functional dyspepsia is poor. It is still controversial whether these pathophysiological factors are responsible for specific symptoms in functional dyspepsia.(2)

While mechanism of functional dyspepsia is unclear, treatment has also been far from satisfactory. Proton pump inhibitor has been recommended as the first line treatment for functional dyspepsia and it has been shown that the use of PPI is associated with a 14% reduction in risk of persistent dyspepsia compared to placebo.(3) However, the mechanism of symptom relief is unclear. While PPI exerts its effect primarily through suppression of acid-induced symptoms, recent studies have shown that PPI may affect gastric motility function such as gastric volume, gastric emptying and trigger of migratory motor complex.(4;5) Most of these studies were performed on healthy volunteers who received only a very short course of PPI. The correlation between symptom and gastric emptying is lacking in these studies.

Aims

- To evaluate the effect of esomeprazole on gastric emptying

- To evaluate the relationship between dyspeptic symptom and gastric emptying

Hypothesis

Long-term PPI relieves dyspeptic symptom through acceleration of gastric emptying rate

Study design

Double-blind randomized placebo-controlled trial

Baseline assessment

- Demographic: age, gender

- Anthropometric measurements: body mass index, height, weight and waist circumference

- FGI Screening Questionnaire (v. 2, 20090106) for screening of functional

gastrointestinal disorder according to Rome III criteria.

- Functional dyspepsia symptom questionnaire (FDSQ) (20080416): an 8-item dyspeptic

symptom score questionnaire: 4-point Likert scale for assessment of epigastric pain, epigastric burning, belching, bloating, postprandial fullness, early satiation, nausea and vomiting and a global dyspeptic symptom assessment.

- GERD Symptom questionnaire (GERDSQ) (20080416): GERD symptom score questionnaire.

- Irritable Bowel Syndrome Symptom questionnaire (IBSSQ) (20080428): IBS symptom score

questionnaire.

Satiety test and ghrelin profile

After an overnight fast, the patients are instructed to ingest Ensure® (1. 06 kcal/ml; 22% fat, 64% carbohydrate, and 14% protein) at constant rate of 30ml/min, and complete a Fullness Rating Scale (FRS) at 3-min intervals (ie. 0min, 3min, 6min…). The test will stop when a score of 4, which is equivalent to unbearable fullness, is reached in FRS. The volume (calorie) of Ensure that is ingested will be recorded and it serves as surrogate marker of satiety function. Serial blood sample (2ml each) will also be taken at 0, 60, 120min during test for assay of ghrelin and gastrin profile. If the test is stopped before 120 minutes, the remaining blood will still be taken according to schedule.

Gastric emptying test with BreathID

Measurement of gastric emptying rate of solid meal will be accomplished using 13C-octanoic acid breath test within 7 days after satiety test. After 12-hour fasting, the patient is required to ingest an omelet with bread that contains 100 ul of 13C-octanoic acid dissolved in egg yolk. The exhaled 13CO2 will be measured continuously via a nasal cannula connected to a breath test device (BreathID, Exalenz Ltd., Israel) for 4 hours. 13CO2 is released after the 13C-octanoic acid enriched meal is emptied into the stomach and digested in duodenum.

Randomization of treatment

After baseline investigations, patients will be randomly assigned to either Esomeprazole 20 mg daily or identical looking placebo for 8 weeks. The random allocation sequence will be obtained from a computer-generated list of random numbers in blocks of 10. Concealed allocation is achieved by an independent staff who assigns treatments according to consecutive numbers in sealed envelopes. Study medications are dispensed as sealed packages in consecutive numbers. Medication adherence is measured by pill counts during interval visits.

Follow-up assessment

The patients will report their individual dyspeptic symptoms on weekly basis using a self-administered symptom questionnaire. At week 4 and week 8, they will need to give an additional rating on their overall symptom response using global symptom assessment. The patients are required to give a dichotomous response of either "yes" or "no" to the question stating "Do you have adequate relief of symptoms over the past 7 days?". Satiety test and blood sampling, gastric emptying study will be repeated at the end of 8-week treatment.

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients with functional dyspepsia that fulfill Rome III criteria attending GI clinic

or endoscopy center

- Age >18

- Provision of written consent

- Negative upper endoscopy (oesophagogastroduodenoscopy or OGD) finding

Exclusion Criteria:

- Diabetes mellitis

- Frequent (once or more per week) acid reflux or heartburn symptoms

- Concurrent medications that affect GI motility

- History of gastric surgery

- Organic disease as cause of dyspepsia

- H. pylori infection

- Use of PPI or NSAID in the past 4 weeks

- Pregnancy

- Known hypersensitivity to PPI

Justin C.Y. Wu, MBChB(CUHK), Phone: (852) 2632-3593, Email: justinwu@cuhk.edu.hk

Prince of Wales Hospital, Hong Kong, Hong Kong

Institute of Digestive Disease

Starting date: September 2009
Ending date: June 2010
Last updated: August 3, 2009