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Oral Glucocorticosteroid in the Treatment of Severe Asthma Exacerbation in Hospitalized Patients

Information source: Hamamatsu University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Asthma

Intervention: methylprednisolone sodium succinate (mPSL) (Drug); prednisolone (PSL) (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Hamamatsu University

Official(s) and/or principal investigator(s):
Kingo Chida, MD,PhD, Study Chair, Affiliation: Hamamatsu University


A comparison of oral prednisolone administration with intravenous methylprednisolone infusion in the treatment of acute asthma exacerbation in hospitalized patients. Oral glucocorticosteroids administration may be effective as intravenous high-dose methylprednisolone infusion.

Clinical Details

Official title: Phase 4, Randomized Study of Oral Glucocorticosteroid Administration in the Treatment of Acute Severe Asthma Exacerbation in Hospitalized Patients

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Efficacy of oral prednisolone for the treatment of acute asthma

Secondary outcome: The safety of oral prednisolone for the treatment of acute asthma


Minimum age: 16 Years. Maximum age: 80 Years. Gender(s): Both.


Inclusion Criteria:

- Asthma patients, who need hospitalized treatment, who do not respond with initial

treatment including bronchodilator and IV methylprednisolone therapy Exclusion Criteria:

- Need for incubation

- With severe complications

- Received systemic glucocorticosteroid therapy in the previous 4 weeks

Locations and Contacts

Hamamatsu University School of Medicine, Hamamatsu, Japan
Additional Information

Starting date: June 2007
Last updated: September 5, 2011

Page last updated: August 23, 2015

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