Capsaicinoid Ingestion, Human Metabolism and Exercise (Phase 2)
Information source: University of Prince Edward Island
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Metabolism; Exercise
Intervention: Capsaicin (Dietary Supplement); Placebo (Dietary Supplement)
Phase: Phase 0
Status: Recruiting
Sponsored by: University of Prince Edward Island Overall contact:
Jamie F Burr, PhD, Phone: (902)620-5225, Email: jburr@upei.ca
Summary
Capsaicinoids (the active ingredient in hot peppers) have been shown to cause a moderate
increase in energy expenditure (50 kcal/day) as well as reductions in appetite, energy
intake, and (visceral) adiposity. As such, there is considerable interest in capsaicinoid
for weight loss supplements. Owing to the fact that these changes are believed to be driven
by catecholamine release and alterations in fat oxidation, there is growing belief that
capsaicin may also offer potential ergogenic benefits (performance enhancement) during
exercise, similar to the affect of caffeine, which works through similar pathways. Of
particular interest are the recent findings that free-fatty acids in the blood are elevated
2-2. 5hrs post ingestion, yet changes in typical cardiovascular or sympathetic nervous tone
indicators (heart rate, blood pressure) were unaffected, suggesting some of the negative
consequences of other stimulants may be avoided. At present, however, more in depth
investigations of the effects on endothelial function, vascular autonomic tone and
inflammation are lacking.
Although there are some indications that capsaicinoid ingestion may alter factors associated
exercise performance (such as increased fat oxidation for glucose sparing), to date these
studies have primarily used very low exercise intensities wherein these effects are
typically unnecessary, and results are not generalizable to the typical race intensities of
endurance sport competition. Performance measures have also been a noticeably absent outcome
from research to date.
Hypotheses: 1), Exercise performance will improve, at a level similar to those demonstrated
for caffeine ingestion 2) ratings of perceived exertion will go down with the effect of
causing intensity to go up 3) During sustained aerobic activity approaching the aerobic
threshold alterations in substrate use will be minimal (but possibly meaningful in regard to
performance); alterations at rest will be more pronounced. 4) acute alterations (6o min post
single dose) in blood pressure, HRV, arterial stiffness and RMR will mirror the effects
observed for more prolonged exposure in phase 1.
Clinical Details
Official title: The Physiological Effects of Capsaicinoid Ingestion on Human Metabolism and Exercise Performance
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Outcomes Assessor)
Primary outcome: Performance
Secondary outcome: Substrate Use
Eligibility
Minimum age: 18 Years.
Maximum age: 45 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
Subjects will be male or female, 18 yr - 45yr and free from any known or suspected chronic
conditions. General health and suitability to participate in an exercise/health research
study will be confirmed through use of the PAR-Q+ screening questionnaire
Exclusion Criteria:
Any participant who has a positive answer to a screening question will be required to seek
physician approval prior to any physical exercise. Baseline arrhythmia (tachycardia
(>100pbm) and systolic or diastolic hypertension (>140/90 mmHg) will also be reason for
exclusion. During baseline anthropometric assessment we will confirm that participants all
fall within a typical BMI range (20-30 kg/m2) of either "normal" weight or "overweight",
but not "underweight" or "obese". Persons who take cardiovascular medications, metabolic
medications, smoke cigarettes, excessively consume alcohol, are prone to heartburn, or
have a previous diagnosis of hyperlipidemia or hyperinsulemia will also be excluded
Locations and Contacts
Jamie F Burr, PhD, Phone: (902)620-5225, Email: jburr@upei.ca
UPEI, Charlottetown, Prince Edward Island C1A4P3, Canada; Recruiting
Jamie F Burr, PhD, Phone: (902)620-5225, Email: jburr@upei.ca
Additional Information
Starting date: June 2014
Last updated: June 6, 2014
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