Marijuana Drug Discrimination and Self-Administration
Information source: National Institute on Drug Abuse (NIDA)
Information obtained from ClinicalTrials.gov on October 19, 2009
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Marijuana Abuse
Intervention: THC (delta-9 tetrahydrocannabinol), d-amphetamine, oral THC (Drug)
Phase: N/A
Status: Recruiting
Sponsored by: National Institute on Drug Abuse (NIDA) Official(s) and/or principal investigator(s):
Leslie Lundahl, PhD, Principal Investigator, Affiliation: Wayne State University
Overall contact:
Lisa Sulkowski, Phone: (313) 993-3966, Email: lsulkows@med.wayne.edu
Summary
This study is designed to investigate the associations among marijuana's discriminative
stimulus, reinforcing, subjective (e. g. craving) and physiological effects, and to assess
the relative ability of oral THC to block these effects.
Clinical Details
Official title: Smoked Marijuana Discrimination and Marijuana Choice in Humans: A Laboratory Mode
Study design: Case-Only, Prospective
Detailed description:
Volunteers will be asked to live on a research unit for up to twenty-six (26) consecutive
nights and will participate in a total of 38 study sessions held on 19 weekdays. Each
session will last approximately four hours and there will be two sessions per day, therefore
each study day will last approximately eight hours. In addition to these study sessions, an
orientation session will be conducted on the Friday prior to admission to the inpatient
unit, and a lottery session will be held on the last day of the study.
During each study session participants will be asked to smoke a cigarette. The cigarette
may contain marijuana or it may contain placebo (a blank). Participants will also be asked
to swallow a capsule 2-hours prior to smoking the cigarette. The capsule could contain
placebo (a blank), THC (delta-9 tetrahydrocannabinol, which is the active ingredient in
marijuana responsible for its mood effects), or d-amphetamine. We will have participants
answer questions about how the drugs make them feel and measure their vitals signs (blood
pressure, heart rate, and oxygen saturation) will be measured using a non-invasive
(external) vitals monitor.
Eligibility
Minimum age: 21 Years.
Maximum age: 45 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Female and male volunteers must be in generally good health (as indicated by results
from medical history, physical exam, electrocardiogram, urine and blood samples at
screening and upon arrival at the laboratory (urine samples only).
- Psychiatric examination must meet DSM-IV criteria for Cannabis Dependence.
- Individuals must be legally and mentally competent to provide written informed
consent.
- Those who are unable to give their voluntary informed consent will not be accepted.
Exclusion Criteria:
- Current serious Axis I disorder (except Cannabis or Nicotine Dependence), neurologic,
cardiovascular, pulmonary or systemic (e. g., renal, hepatic) disease; cognitive
impairment; pregnancy (urine test), lactation (self-report), or not using
(self-report) medically approved contraceptives.
- Applicants who express interest in treatment will not be accepted for study and will
be provided with a treatment referral.
Locations and Contacts
Lisa Sulkowski, Phone: (313) 993-3966, Email: lsulkows@med.wayne.edu
Wayne State University, Detroit, Michigan 48207, United States; Recruiting
Leslie Lundahl, PhD, Phone: 313-993-1374, Email: llundahl@med.wayne.edu
Additional Information
Starting date: April 2009
Ending date: April 2011
Last updated: October 15, 2009
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