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A Comparison of Etomidate and Ketamine for Anesthesia Induction in Coronary Artery Bypass Graft Surgery

Information source: Baskent University
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Coronary Artery Bypass Surgery

Intervention: Ketamine (Drug); Etomidate (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: Baskent University

Official(s) and/or principal investigator(s):
Özgür Kömürcü, Principal Investigator, Affiliation: Baskent University, Faculty of Medicine

Overall contact:
Özgür Kömürcü, Phone: +90 312 215 99 41, Email: zgrkom@gmail.com


The aim of this study is to determine whether ketamine is an acceptable alternative to etomidate for anesthesia induction in coronary artery bypass graft surgery in terms of hemodynamic stability and also to compare these agents regarding their effect on adrenal gland steroid synthesis in these patients.

Clinical Details

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: A more than 15% change in mean arterial pressure and heart rate after anesthesia induction

Secondary outcome: Adrenal gland steroid synthesis suppression


Minimum age: 30 Years. Maximum age: 80 Years. Gender(s): Both.


Inclusion Criteria:

- Patients scheduled for elective coronary artery bypass graft surgery with

cardiopulmonary bypass

- Patient's written informed consent for study participation

- Ejection fraction ≥ 35%

Exclusion Criteria:

- Allergy to study drugs

- Redo surgery

Locations and Contacts

Özgür Kömürcü, Phone: +90 312 215 99 41, Email: zgrkom@gmail.com

Baskent University, Faculty of Medicine, Ankara, Çankaya 06490, Turkey; Recruiting
Additional Information

Starting date: March 2011
Last updated: June 30, 2011

Page last updated: August 20, 2015

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