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Use of Oxybutynin to Treat Axillary Hyperhidrosis

Information source: Grupo de Cirurgia Vascular
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Axillary Hyperhidrosis; Osmidrosis

Intervention: Oxybutynin (Drug); Placebo (Drug)

Phase: N/A

Status: Completed

Sponsored by: Grupo de Cirurgia Vascular

Official(s) and/or principal investigator(s):
Nelson Wolosker, MD, PhD, Principal Investigator, Affiliation: Hospital das Clinicas, University of Sao Paulo


The objective of this study was to evaluate the effectiveness and patient satisfaction with the use of oxybutynin at low doses for treating axillary hyperhidrosis in a large series of patients.

Clinical Details

Official title: Use of Oxybutynin to Treat Axillary Hyperhidrosis

Study design: Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome:

Effectiveness of treatment by a clinical questionnaire

Effectiveness of treatment using a clinical questionnaire

Secondary outcome: Treatment of hyperhidrosis at other sites


Minimum age: 14 Years. Maximum age: 55 Years. Gender(s): Both.


Inclusion Criteria:

- patients with axillary hyperhidrosis

Exclusion Criteria:

- glaucoma and micturition disorders, pregnancy

Locations and Contacts

Hospital das Clinicas da FMUSP, Sao Paulo 04534000, Brazil
Additional Information

Related publications:

Wolosker N, Yazbek G, de Campos JR, Munia MA, Kauffman P, Jatene FB, Puech-Leao P. Quality of life before surgery is a predictive factor for satisfaction among patients undergoing sympathectomy to treat hyperhidrosis. J Vasc Surg. 2010 May;51(5):1190-4. doi: 10.1016/j.jvs.2009.11.078. Epub 2010 Mar 29.

de Campos JR, Wolosker N, Yazbek G, Munia MA, Kauffman P, Puech-Leao P, Jatene FB. Comparison of pain severity following video-assisted thoracoscopic sympathectomy: electric versus harmonic scalpels. Interact Cardiovasc Thorac Surg. 2010 Jun;10(6):919-22. doi: 10.1510/icvts.2009.225383. Epub 2010 Mar 16.

Yazbek G, Wolosker N, Kauffman P, Campos JR, Puech-Leão P, Jatene FB. Twenty months of evolution following sympathectomy on patients with palmar hyperhidrosis: sympathectomy at the T3 level is better than at the T2 level. Clinics (Sao Paulo). 2009;64(8):743-9. doi: 10.1590/S1807-59322009000800006.

Munia MA, Wolosker N, Kaufmann P, de Campos JR, Puech-Leão P. Sustained benefit lasting one year from T4 instead of T3-T4 sympathectomy for isolated axillary hyperhidrosis. Clinics (Sao Paulo). 2008 Dec;63(6):771-4.

Wolosker N, Yazbek G, Ishy A, de Campos JR, Kauffman P, Puech-Leão P. Is sympathectomy at T4 level better than at T3 level for treating palmar hyperhidrosis? J Laparoendosc Adv Surg Tech A. 2008 Feb;18(1):102-6. doi: 10.1089/lap.2007.0030.

Munia MA, Wolosker N, Kauffman P, de Campos JR, Puech-Leão P. A randomized trial of T3-T4 versus T4 sympathectomy for isolated axillary hyperhidrosis. J Vasc Surg. 2007 Jan;45(1):130-3.

Starting date: January 2007
Last updated: May 5, 2010

Page last updated: August 23, 2015

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