Ambrisentan is an endothelin receptor antagonist used for the treatment of pulmonary
hypertension (PH). Based on research suggesting a role for endothelin-1 in the pathogenesis
of idiopathic pulmonary fibrosis (IPF) and the poor prognosis for patients with IPF who are
also diagnosed with PH, this study was designed to evaluate the effectiveness and safety of
ambrisentan in that patient population.
Minimum age: 35 Years.
Maximum age: 80 Years.
Gender(s): Both.
Medizinische Universität Graz, Graz 8036, Austria
Universitatsklinikum Innsbruck, Innsbruck, Austria
Medizinische Universität Wien, Vienna 1090, Austria
Charite-Universitatsmedizin Berlin, Berlin, Germany
Evangelische Lungenklinik Berlin, Berlin 13125, Germany
Krankenhaus Donaustauf der LVA, Donaustauf 93093, Germany
Universitatsklinikum Freiburg, Freiburg 79095, Germany
Universitat Greifswald, Greifswald 17475, Germany
Medizinische Hochschule Hannover, Hannover 30625, Germany
Thorax Klinik, Heidelberg 66126, Germany
LMU Klinikum der Universitat, Munchen, Germany
Azienda Ospedaliero Universitaria, Catania, Italy
Presidio Ospedaliero G.B. Morgagni, Forli, Italy
Unita Funzionale di Pneumologia e Fisiopatologia Respiratoria, Milano 20132, Italy
Ospedale S.Giuseppe Fatebenefratelli, Milan, Italy
Azienda Ospedaliera di Padova, Padova, Italy
Instituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione, Palermo, Italy
Policlinico Universitario Tor Vergata, Rome, Italy
Azienda Ospedaliera Universitaria Senese, Siena 53100, Italy
Centro delle Interstiziopatie Polmonari e Malattie Rare del Polmone, Torino 10043, Italy
Papworth Hospital NHS Foundation Trust, Cambridge CB23 3RE, United Kingdom
University Hospital Aintree, Liverpool, United Kingdom
University College Hosptial, London, United Kingdom
Royal Hallamshire Hospital, Sheffield, United Kingdom
University of Alabama at Birmingham, Birmingham, Alabama 35294, United States
Peter Loughheed Center- Calgary General Hospital, Calgary, Alberta T1Y 6J4, Canada
Mayo Clinic Arizona, Scottsdale, Arizona 85259, United States
University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada
University of California Davis, Davis, California 95817, United States
David Geffen School of Medicine UCLA, Los Angeles, California 90095, United States
University of California San Diego Medical Center, San Diego, California 92103, United States
University of California at San Francisco, San Francisco, California 94143, United States
Stanford University, Stanford, California 94305, United States
University of Colorado Heatlh Sciences Center, Aurora, Colorado 80045, United States
Bay Area Chest Physicians, Clearwater, Florida 33756, United States
University of Florida, Gainesville, Florida 32610, United States
University of Miami Medical Center, Miami, Florida 33136, United States
Sarasota Memorial Hospital, Sarasota, Florida 34239, United States
Suncoast Lung Center, Sarasota, Florida 34233, United States
Cleveland Clinic Florida, Weston, Florida 33331, United States
Atlanta Institute for Medical Research, Decatur, Georgia 30030, United States
University of Chicago, Chicago, Illinois 60637, United States
Kentuckiana Pulmonary Association, Louisville, Kentucky, United States
Maine Medical Center, Portland, Maine, United States
Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States
Beth Israel Deacones Medical Center, Boston, Massachusetts 02215, United States
Boston University Medical Center, Boston, Massachusetts 02118, United States
Brigham and Women's Hospital, Boston, Massachusetts 02115, United States
Tufts Medical Center, Boston, Massachusetts 02111, United States
University of Michigan Health Systems, Ann Arbor, Michigan 48109, United States
Mayo Clinic Rochester, Rochester, Minnesota 55905, United States
Washington University, St Louis, Missouri 63110, United States
Creighton University Center for Allergy & Asthma, Omaha, Nebraska 68131, United States
Dartmouth Medical School, Lebanon, New Hampshire 03756, United States
St. Vincents Hospital, Sydney, New South Wales 2010, Australia
Albany Medical Center, Albany, New York 12208, United States
Winthrop University Hospital, Mineola, New York 11501, United States
North Shore Health System, New Hyde Park, New York 11040, United States
Columbia University, New York, New York 10032, United States
Mount Sinai School of Medicine, New York, New York 10029, United States
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States
Duke University Medical Center, Durham, North Carolina 27710, United States
The Lindner Center for Research & Education at The Christ Hospital, Cincinnati, Ohio 45219, United States
Cleveland Clinic Foundation, Cleveland, Ohio 44195, United States
University Hospitals of Cleveland Case Western, Cleveland, Ohio 44106, United States
Ohio State University, Columbus, Ohio 43210, United States
London Health Sciences Centre, London, Ontario N6A 5W9, Canada
Toronto General Hospital, Toronto, Ontario, Canada
Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
Temple University School of Medicine, Philadelphia, Pennsylvania 19140, United States
Alleghany General Hospital, Pittsburgh, Pennsylvania 12512, United States
University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, United States
Centre Hospitalier De L'Universite de Montreal, Montreal, Quebec H2W 1T8, Canada
Sir Mortimer B. Davis Jewish General Center, Montreal, Quebec, Canada
Centre de Pneumologie de L'Hospital Laval, Sainte foy, Quebec G1V 4G5, Canada
The Prince Charles Hospital, Chermside, Queensland 4032, Australia
Medical University of South Carolina, Charleston, South Carolina, United States
Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States
University of Texas Southwestern, Dallas, Texas 75390, United States
Baylor College of Medicine, Houston, Texas 77030, United States
University of Utah, Salt Lake City, Utah 84108, United States
Inova Heart Institiute and Vascular Institute, Falls Church, Virginia 22042, United States
Virginia Commonwealth University Health System, Richmond, Virginia 23298, United States
Providence Everett Medical Center, Everett, Washington 98201, United States
Royal Perth Hospital, Perth, Western Australia 6000, Australia