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Pharmacogenetic Study of Methylphenidate in Attention Deficit/Hyperactivity Disorder(ADHD)

Information source: Hallym University Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Attention Deficit Disorder With Hyperactivity; Methylphenidate; Pharmacogenetics

Intervention: norepinephrine transporter polymorphism, (Genetic)

Phase: Phase 4

Status: Completed

Sponsored by: Hallym University Medical Center


The noradrenergic system plays a known role in attentional systems and suspected causal role in attention deficit/hyperactivity disorder(ADHD).Methylphenidate also has been suspected as a inhibitor of norepinephrine transporter(SLC6A2). The investigators hypothesis is that norepinephrine transporter polymorphism is associated with responses and adverse effects of OROS-methylphenidate in treatment of ADHD.

Clinical Details

Official title: Association Between Norepinephrine Transporter Polymorphism and Response of Methylphenidate

Study design: Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Korean ADHD Rating scale-parent version (KARS)

Secondary outcome: Barkely side effect rating scale


Minimum age: 6 Years. Maximum age: 18 Years. Gender(s): Both.


Inclusion Criteria:


- Physically healthy

Exclusion Criteria:

- Neurological illness

- Concurrent additional psychiatric treatment

- < IQ 70

- Psychotic disorder

- Major mood disorder needed other psychiatric medication

- Significant suicidal ideation

- Pervasive developmental disorder

Locations and Contacts

Hallym University Sacred Heart Hospital, Anyang, Gyeonggi-do, Korea, Republic of
Additional Information

Starting date: October 2005
Last updated: October 4, 2011

Page last updated: August 23, 2015

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