The objective of this study is to determine the bioequivalence of Glipizide GITS (Glucotrol
XL) 2. 5 mg tablets manufactured at the Brooklyn, New York facility versus tablets
manufactured at the facility in Barceloneta, Puerto Rico.
Minimum age: 18 Years.
Maximum age: 55 Years.
1. Healthy male and/or female subjects between the ages of 18 and 55 years, inclusive
(Healthy is defined as no clinically relevant abnormalities identified by a detailed
medical history, full physical examination, including blood pressure and pulse rate
measurement, 12-lead ECG and clinical laboratory tests). Subjects below the age of 21
years must have consent from either a parent or guardian in countries having this
2. Body Mass Index (BMI) of approximately 18 to 30 kg/m2; and a total body weight >45 kg
3. Evidence of a personally signed and dated informed consent document indicating that
the subject (or a legally acceptable representative) has been informed of all
pertinent aspects of the trial.
4. Subjects who are willing and able to comply with the scheduled visits, treatment plan,
laboratory tests and other study procedures.
1. Evidence or history of clinically significant hematological, renal, endocrine,
pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or
allergic disease (including drug allergies, but excluding untreated, asymptomatic,
seasonal allergies at time of dosing).
2. Any condition possibly affecting drug absorption (e. g., gastrectomy).
3. A positive urine drug screen.
4. History of regular alcohol consumption exceeding 7 drinks/week for females or 14
drinks/week for men (1 drink = 5 ounces (150 mL) of wine or 12 ounces (360 mL) of beer
or 1. 5 ounces (45 mL) of hard liquor) within 6 months of screening.
5. History or evidence of habitual tobacco- or nicotine-containing products within 3
months of screening or a positive urine or serum cotinine test.
6. Treatment with an investigational drug within 30 days preceding the first dose of
7. 12-lead ECG demonstrating QTc >450 msec at Screening.
8. Sitting blood pressure ?140 mm Hg systolic or ?90 mm Hg diastolic on a single
measurement [confirmed by a single repeat, if necessary] following at least 5 minutes
of rest at Screening.
9. Pregnant or nursing females; females of childbearing potential who are unwilling or
unable to use an acceptable method of non-hormonal contraception as outlined in this
protocol from at least 14 days prior to the first dose of study medication until
completion of follow-up procedures.
10. Use of prescription or nonprescription drugs, vitamins and dietary supplements within
7 days or 5 half-lives (whichever is longer) prior to the first dose of study
medication. Herbal supplements and hormonal methods of contraception (including oral
and transdermal contraceptives, injectable progesterone, progestin subdermal implants,
progesterone-releasing IUDs, postcoital contraceptive methods) and hormone replacement
therapy must be discontinued 28 days prior to the first dose of study medication.
Depo-Provera� must be discontinued at least 6 months prior to the first dose of study
medication. As an exception, acetaminophen may be used at doses of ?1g/day. Other
exceptions may be granted by a qualified member of Pfizer study management.
11. Blood donation of approximately 1 pint (500 mL) within 56 days prior to dosing.
12. Unwilling or unable to comply with the Lifestyle guidelines described in this
13. Other severe acute or chronic medical or psychiatric condition or laboratory
abnormality that may increase the risk associated with study participation or
investigational product administration or may interfere with the interpretation of
study results and, in the judgment of the investigator, would make the subject
inappropriate for entry into this study.