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Antiemetic Effect of the Addition of Ondansetron to the Morphine Solution in Patient-Controlled Analgesia (PCA)

Information source: Khon Kaen University
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Postoperative Nausea and Vomiting

Intervention: ondansetron adding in PCA (Drug)

Phase: N/A

Status: Completed

Sponsored by: Khon Kaen University

Official(s) and/or principal investigator(s):
Polpun Boonmak, MD, Study Director, Affiliation: lecturer in Khon Kaen University


PCA morphine always introduces nausea and vomiting during the postoperative period. Ondansetron can reduce PONV (postoperative nausea vomiting). We, the researchers at Khon Kaen University, are trying to add ondansetron in PCA morphine. Patients receive a small dose of ondansetron when they request morphine.

Clinical Details

Study design: Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Placebo Control, Parallel Assignment, Efficacy Study

Primary outcome: PONV


Minimum age: 15 Years. Maximum age: 60 Years. Gender(s): Both.


Inclusion Criteria:

- Age between 15-60 years old

Exclusion Criteria:

- History of motion sickness, smoking

Locations and Contacts

Khon Kaen university, Srinagarind Hospital, Muang, Khon Kaen 40002, Thailand
Additional Information

Starting date: January 2005
Last updated: October 31, 2007

Page last updated: June 20, 2008

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