Ketamine Versus Etomidate for Rapid Sequence Intubation
Information source: Minneapolis Medical Research Foundation
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Airway Control; Anesthesia; Intubation; Complication
Intervention: Ketamine (Drug); Etomidate (Drug)
Phase: Phase 4
Status: Suspended
Sponsored by: Minneapolis Medical Research Foundation Official(s) and/or principal investigator(s): Brian E Driver, MD, Principal Investigator, Affiliation: Hennepin County Medical Canter
Summary
The purpose of this study is to compare the effectiveness and safety of ketamine and
etomidate during rapid sequence intubation (RSI).
Clinical Details
Official title: Ketamine Versus Etomidate for Sedation of Emergency Department Patients During Rapid Sequence Intubation
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: Mortality
Secondary outcome: Mortality in Sepsis and Septic ShockFirst-pass success Number of intubation attempts Post-intubation sedation Post-intubation hypoxemia Hypotension SOFA score Peak and Plateau pressure
Detailed description:
This study is a randomized controlled trial of etomidate versus ketamine during rapid
sequence intubation (RSI). RSI refers to the process by which patients who require
emergency airway management undergo sedation and paralysis prior to insertion of an
endotracheal tube(airway tube). Patients who require intubation will be randomized to have
intubation performed with either ketamine or etomidate. All other care will be at the
discretion of the treating physicians. The purpose of this study is to compare the efficacy
and safety of ketamine and etomidate during rapid sequence intubation.
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- 18 years of age
- Undergoing rapid sequence intubation (RSI) in the Emergency Department
Exclusion Criteria:
- Known contraindication to ketamine or etomidate
- Patient declines participation in the trial by wearing a bracelet marked "KvE
declined"
- Prisoner
Locations and Contacts
Hennepin County Medical Center, Minneapolis, Minnesota 55415, United States
Additional Information
Public description of study protocol.
Starting date: September 2013
Last updated: October 23, 2014
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