DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Eplerenone Versus Spironolactone as Treatment of Ascites Due to Liver Cirrhosis; a Study of Efficacy and Side Effects

Information source: Region Skane
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Ascites; Cirrhosis

Intervention: Eplerenone (Drug)

Phase: Phase 2

Status: Recruiting

Sponsored by: Emma Nilsson

Overall contact:
Emma Nilsson, MD, Phone: +4646177706, Email: emma.nilsson@skane.se

Summary

This study compares Spironolactone, a non-selective aldosterone antagonist, with Eplerenone, a selective aldosterone antagonist, regarding efficacy and hormonal side effects when treating male cirrhotic patients with uncomplicated ascites over a 6 month period. The investigators hypothesis is that Eplerenone is as effective as Spironolactone as treatment of ascites with less side effects such as painful gynecomastia.

Clinical Details

Official title: Swedish, Multicentered, Randomized Study of Eplerenone Versus Spironolactone as Treatment of Ascites Due to Liver Cirrhosis Regarding Efficacy and Side Effects

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Ascites

Eligibility

Minimum age: 18 Years. Maximum age: 70 Years. Gender(s): Male.

Criteria:

Inclusion Criteria: Male Ascites Cirrhosis

-

Exclusion Criteria: Prior treatment with aldosterone antagonist Uncontrolled heart disease or diabetes Current malignancy Current medication interacting with aldosterone antagonists

Locations and Contacts

Emma Nilsson, MD, Phone: +4646177706, Email: emma.nilsson@skane.se

University Hospital of Skane, Lund, Skane 221 85, Sweden; Recruiting
Emma Nilsson, MD, Principal Investigator

University Hospital of Skane, Lund, Skane 221 85, Sweden; Active, not recruiting

Additional Information

Starting date: February 2013
Last updated: November 19, 2014

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017