DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Chronic Subdural Hematoma - Reduction of Recurrence by Treatment With Angiotensin Converting Enzyme Inhibitors

Information source: Odense University Hospital
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Hematoma, Subdural, Chronic

Intervention: Perindopril (Drug); Placebo (Drug)

Phase: N/A

Status: Terminated

Sponsored by: Odense University Hospital

Official(s) and/or principal investigator(s):
Frantz R Poulsen, MD, PhD, Principal Investigator, Affiliation: Department of Neurosurgery, Odense University Hospital

Summary

The project aims at investigating if treatment with the Angiotensin Converting Enzyme inhibitor Coversyl (perindopril) for 3 months after surgery for chronic subdural hematoma will decrease the risc of recurrence.

Clinical Details

Official title: Chronic Subdural Hematoma - Reduction of Recurrence by Treatment With Angiotensin Converting Enzyme Inhibitors

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Recurrence of chronic subdural hematoma after surgical removal

Secondary outcome: Composition of chronic subdural hematoma fluid

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria: 1. Patients with chronic subdural hematoma that needs surgical evacuation 2. Age > 18 year Exclusion Criteria: 1. Lack of compliance 2. Kidney artery stenosis 3. Stenosis of the aorta 4. Severely decreased kidney function 5. Allergy or intolerance/contraindications toward ACE inhibitors 6. Already in ACE inhibitor treatment 7. Coagulopathies 8. Malignant disorders 9. Fertile women 10. Other neurological disorders 11. Treatment with pharmaceuticals contraindicating treatment with ACE inhibitors

Locations and Contacts

Additional Information

Starting date: July 2009
Last updated: April 7, 2014

Page last updated: August 20, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017