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The Effect of Deep Neuromuscular Blockade on Postoperative Shoulder Tip Pain After Laparoscopic Cholecystectomy

Information source: Yonsei University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Pain, Postoperative

Intervention: Rocuronium (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Yonsei University

Official(s) and/or principal investigator(s):
Yon Hee Shim, MD, PhD, Study Director, Affiliation: Yonsei University


The purpose of this study was to investigate whether there is any difference in incidence of shoulder tip pain after laparoscopic cholecystectomy between the groups with moderate neuromuscular block and deep neuromuscular block.

Clinical Details

Official title: The Effect of Deep Neuromuscular Blockade on Postoperative Shoulder Tip Pain After Laparoscopic Cholecystectomy

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Primary outcome: Shoulder tip pain

Secondary outcome:

Postoperative pain

Postoperative nausea and vomiting

Intraoperative hemodynamics

pulmonary compliance

Satisfaction of the surgeon

Working intrabdominal space

Detailed description: Laparoscopic cholecystectomy has become the gold standard treatment for gall bladder disease. However, 30-50% of patients suffer from shoulder tip pain, which might arise from diaphragm stretch due to pneumoperitoneum. In the previous pilot study, working intra-abdominal space was increased in the condition of deep neuromuscular blockade. And thus investigators hypothesized that the depth of neuromuscular blockade can affect insufflation pressure and intra-abdominal volume, which result in the severity of diaphragm stretch and postoperative shoulder pain. In addition, the depth of neuromuscular blockade can alter pulmonary compliance.


Minimum age: 20 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- physical status by American society of Anesthesiology; 1 or 2 patients

- patients with benign gallbladder disease scheduled for laparoscopic cholecystectomy

Exclusion Criteria:

- patient with myasthenia gravis

- allergy to rocuronium or sugammadex

- patient with shoulder pain disease (Ex. rotator cuff tear)

- psychological disease

- patients who cannot understand Korean

Locations and Contacts

Gangnam severance hospital, Seoul, Korea, Republic of
Additional Information

Starting date: December 2013
Last updated: February 4, 2015

Page last updated: August 23, 2015

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