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Inflammatory Cytokines Profile in Individuals Subjected to Surgical Procedures Using Propofol or Isoflurane

Information source: UPECLIN HC FM Botucatu Unesp
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Patients in Good Health

Intervention: Propofol and isoflurane (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: UPECLIN HC FM Botucatu Unesp

Official(s) and/or principal investigator(s):
Marina Á Mazoti, MsC, Principal Investigator, Affiliation: Department of Pathology, Botucatu Medical School, São Paulo State University, UNESP

Summary

The aim of this study is to assess the profile of cytokines IL-1beta, IL-6, IL-8, IL-10, IL-12 and TNF-alpha under inhalation anesthesia with isoflurane and intravenous anesthesia with propofol in healthy patients subjected to minimally invasive elective surgeries.

Clinical Details

Official title: Inflammatory Cytokines Profile in Individuals Subjected to Surgical Procedures Using Propofol or Isoflurane.

Study design: Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Supportive Care

Primary outcome: Evaluation of cytokines profile

Secondary outcome: Evaluation of pro and anti-inflammatory cytokines

Detailed description: Twenty ASA-I patients, subjected to otorhinolaryngology surgery, were randomly allocated in one group to receive anesthesia with isoflurane 1 MAC (minimum alveolar concentration) (n = 20). Other group with twenty ASA-I patients received propofol 2 to 4 microgram mL-1 (n = 20). Fentanyl 5 mg kg-1 and rocuronium bromide 0. 6 mg kg-1 were also administered to all patients. Venous blood (10 mL) was collected from each patient at each of the following times: before the beginning of surgery and anesthesia (T1), 2 h after the beginning of surgery (T2), and on the day after the anesthetic-surgical procedure (T3). Plasma concentrations of interleukins IL-1beta, IL-6, IL-8, IL-10 and IL-12 and tumor necrosis factor (TNF-alpha) were measured in each sample through flow cytometry technique by using the method Cytometric Bead Array (CBA). Venous blood samples from fifteen volunteers not subjected to stress were also collected as control, and the same cytokines were measured.

Eligibility

Minimum age: 18 Years. Maximum age: 50 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients in good health American Society of Anesthesia status physical I

- Elective minor surgery

- General anesthesia

Exclusion Criteria:

- Smokers

- Alcoholics

- Previous medication or radiation

Locations and Contacts

Botucatu Medical School, UNESP, Botucatu, São Paulo 18603-970, Brazil
Additional Information

Starting date: March 2008
Last updated: April 26, 2010

Page last updated: August 23, 2015

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