A Phase II Neo-adjuvant Study Assessing TCH (Docetaxel, Carboplatin and Trastuzumab), TCL (Docetaxel, Carboplatin and Lapatinib) and the Combination of TCHL (Docetaxel,Carboplatin, Trastuzumab and Lapatinib) in HER-2 Positive Breast Cancer Patients.

Condition(s) targeted: Breast Cancer

Intervention: Docetaxel, Carboplatin and Trastuzumab (Drug); Docetaxel, Carboplatin, Trastuzumab and Lapatinib (Drug)

Phase: Phase 2

Status: Recruiting

Sponsored by: ICORG- All Ireland Cooperative Oncology Research Group

Overall contact:
John Crown, Prof, Phone: 01 2094839

The primary objective of this study is to assess the efficacy of TCH (Docetaxel, Carboplatin and Trastuzumab), TCHL (Docetaxel,Carboplatin, Trastuzumab and Lapatinib and TCL (Docetaxel, Carboplatin and Lapatinib) in neo-adjuvant treatment of HER-2 positive breast cancer, using pathological complete response (pCR) as the primary endpoint (Phase II).

The secondary objectives of this study are:

- To assess the clinical response rate and overall response rate for docetaxel and

carboplatin with trastuzumab alone, lapatinib alone or trastuzumab combined with lapatinib in HER-2 positive breast cancer.

- To assess the relationship between drug exposure and adverse events.

- To examine potential molecular and pharmacological markers of response to trastuzumab

and lapatinib

- To assess Disease-free Survival (DFS) and Overall Survival (OS)

Official title: A Phase II Neo-adjuvant Study Assessing TCH (Docetaxel, Carboplatin and Trastuzumab and TCHL (Docetaxel,Carboplatin, Trastuzumab and Lapatinib) in HER-2 Positive Breast Cancer Patients.

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: pathological complete response

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Female.

Criteria:

Inclusion Criteria:

1. Written informed consent obtained prior to any study-related procedures

2. Age > 18 years

3. Histologically proven breast cancer, for which neo-adjuvant chemotherapy and trastuzumab is considered a valid therapeutic strategy.

4. Patients with the following TNM stages (refer to AJCC 7th Edition - Appendix M) of

breast cancer are eligible:

- T2, T3, T4a, T4b, T4c, T4d which is node negative or node positive

(histologically or cytologically confirmed) or

- Any T with lymph node positive disease (histologically or cytologically

confirmed)

- Patients with multifocal tumours are not excluded; T stage assignment must be

based on the largest tumour.

5. Tumour HER2/neu positive (3+ by IHC or fluorescence in situ hybridization (FISH) positive)

6. Oestrogen and progesterone receptor status known prior to study entry

7. ECOG performance status score <1

8. Cardiac ejection fraction ≥ 50% as measured by echocardiogram or MUGA scan within 3 months prior to randomisation. Note that baseline and on treatment scans should be performed using the same modality and preferably at the same institution

9. The effects of lapatinib on the developing human foetus at the recommended therapeutic dose are unknown. For this reason, women of child-bearing potential and men must agree to use adequate contraception (non-hormonal or barrier method of birth control, abstinence or a vasectomy partner) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately.

- If applicable, post-menopausal status will be defined as patients who are

amenorrheic for > 1 year or for a shorter duration if FSH, LH and/or oestradiol levels are within the post-menopausal range

10. Patient is accessible and willing to comply with treatment, tissue acquisition and follow up.

11. Formalin-fixed paraffin-embedded tissue available from diagnostic biopsy and/or definitive surgical intervention

- Where possible fresh frozen tissue will be sought as outlined per protocol.

12. Adequate bone marrow function within 14 days prior to randomisation as defined by the following laboratory values

- Absolute neutrophil count > 1. 0 x 109/L

- Haemoglobin > 9. 0 g/dL

- Platelet count > 100 x 109/L

13. Adequate renal function within 14 days prior to randomisation as defined by:

- Serum creatinine < 1. 25 x upper limit of normal (ULN), defined by institution

- Serum creatinine clearance of > 60 mg/ml/min

14. Adequate hepatic function within 14 days prior to randomisation as defined by:

- Total bilirubin < 1. 0 x upper limit of normal (ULN). Patients with Gilbert's

syndrome prior to study entry must have total bilirubin < 3X ULN.

- Alkaline phosphatase and AST/ALT within parameters specified in protocol

15. Able to swallow and retain oral medication

16. Patients must be deemed potentially operable following neo-adjuvant treatment.

Exclusion Criteria:

1. Prior therapy with systemic cytotoxic chemotherapy Lapatinib or Trastuzumab.

2. Prior taxanes

3. Radiotherapy (Except for radiotherapy localised to radiotherapy to a primary squamous or basal cell skin cancer).

4. Patients with metastatic disease (M1).

5. Concurrent therapy with any other non-protocol anti-cancer therapy

6. History of any other malignancy within the past 5 years, with the exception of non-melanoma skin cancer, in situ carcinoma of the breast (ductal or lobular) or carcinoma-in-situ of the cervix.

7. Current therapy with any hormonal agent such as raloxifene, tamoxifen, or other selective oestrogen receptor modulators (SERMs), either for osteoporosis or prevention of breast cancer. Patients must have discontinued these agents 14 days prior to enrollment.

8. Concurrent treatment with ovarian hormonal replacement therapy. Prior treatment must be stopped prior to enrollment.

9. Pre-existing motor or sensory neurotoxicity of a severity > Grade 2 by NCI-CTCAE version 4. 0.

10. Poorly controlled hypertension (e. g. systolic > 180mm Hg or diastolic > 100mm Hg.)

11. Any history of myocardial infarction, angina pectoris or congestive heart failure. Patients on current therapy for arrythmias are excluded. For other patients with a history of self-limiting cardiac diseases (e. g. pericarditis, temporary secondary arrythmias) more than 1 year must have past prior to enrollment on the study

12. Inflammatory bowel disease or other bowel condition causing chronic diarrhoea, requiring active therapy.

13. Active, uncontrolled infection requiring parenteral antimicrobials or any condition requiring maintenance therapeutic (i. e. non-replacement) doses of corticosteroids.

14. The presence of any other medical or psychiatric disorder that, in the opinion of the treating physician, would contraindicate the use of the drugs in this protocol or place the patient at undue risk for treatment complications

15. Male patients.

16. Patients with known hypersensitivity to Chinese hamster ovary products or other recombinant human or humanized antibodies and/or known hypersensitivity to any of the study drugs or their ingredients (e. g., polysorbate 80 in docetaxel)

17. Pregnant women are excluded from this study because lapatinib is member of the 4-anilinoquinazoline class of kinase inhibitors with the potential for teratogenic or abortifacient effects. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with lapatinib, breastfeeding should be discontinued if the mother is treated with lapatinib

18. HIV-positive patients receiving combination anti-retroviral therapy are excluded from the study because of possible pharmacokinetic interactions with lapatinib. Appropriate studies will be undertaken in patients receiving combination anti-retroviral therapy when indicated.

19. Patients with GI tract disease resulting in an inability to take oral medication, malabsorption syndrome, a requirement for IV alimentation, prior surgical procedures affecting absorption, uncontrolled inflammatory GI disease (e. g., Crohn's, ulcerative colitis).

20. Concomitant requirement for medication classified as CYP3A4 inducers or inhibitors as defined in Table 2.

21. Have current active hepatic or biliary disease (with exception of patients with Gilbert's syndrome, asymptomatic gallstones, liver metastases or stable chronic liver disease per investigator assessment)

John Crown, Prof, Phone: 01 2094839

Cork University Hospital, Cork, Ireland; Recruiting
Seamus O'Reilly, Phone: (0)21 4546400
Seamus O'Reilly, Dr, Principal Investigator

Bon Secours Hospital, Cork, Ireland; Recruiting
Conleth Murphy, Dr, Phone: 021 4542807
Conleth Murphy, Dr, Principal Investigator

Beaumont Hospital, Dublin, Ireland; Recruiting
Bryan Hennessy, Dr, Phone: (01) 809 3000
Bryan Hennessy, Dr, Principal Investigator

Mater Misericordiae University and Private Hospitals, Dublin, Ireland; Recruiting
John McCaffrey, Dr, Phone: 01 803 2000
John McCaffrey, Prof, Principal Investigator

Galway University Hospital, Galway, Ireland; Recruiting
Maccon Keane, Dr, Phone: (0)91 524222
Maccon Keane, Dr, Principal Investigator

Letterkenny General Hospital, Letterkenny, Ireland; Recruiting
Karen Duffy, Dr, Phone: 074-9125888
Karen Duffy, Dr, Principal Investigator

Mid-Western Regional Hospital, Limerick, Ireland; Recruiting
Rajnish Gupta, Dr, Phone: 061 301111
Rajnish Gupta, Prof, Principal Investigator

Sligo General Hospital, Sligo, Ireland; Recruiting
Michael Martin, Dr, Phone: (071) 9171111
Michael Martin, Dr, Principal Investigator

Waterford Regional Hospital, Waterford, Ireland; Recruiting
Miriam O'Connor, Dr, Phone: (051) 848000
Miriam O'Connor, Dr, Principal Investigator

St James's Hospital, Dublin, Leinster, Ireland; Recruiting
John Kennedy, Dr, Phone: (01) 410 3000
John Kennedy, Dr, Principal Investigator

St Vincent's University Hospital, Dublin, Leinster, Ireland; Recruiting
John Crown, Prof, Phone: 01 221 4000
John Crown, Prof, Principal Investigator

Starting date: October 2010
Last updated: November 6, 2012