Effects of Exercise Training in Chronic Obstructive Pulmonary Disease Versus Alpha-1-Antitrypsin-deficiency-patients
Information source: Klinikum Berchtesgadener Land der Schön-Kliniken
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Chronic Obstructive Pulmonary Disease; Alpha-1-antitrypsin-deficiency
Intervention: exercise training (Procedure)
Phase: N/A
Status: Completed
Sponsored by: Klinikum Berchtesgadener Land der Schön-Kliniken Official(s) and/or principal investigator(s): Klaus Kenn, Dr. med., Study Chair, Affiliation: Klinikum Berchtesgadener Land, Schön Klinik
Summary
Chronic Obstructive Pulmonary Disease (COPD)-patients (caused by smoking-level) and
Alpha-1-Antitrypsin-deficiency patients showed different developments during rehabilitation
in regard to improvement of 6-minute-walking distance. The aim of this study is to
investigate differences between training adaptations in COPD-patients and Alpha-1-deficiency
patients. Both groups take part in a standardized multimodal 3-week-rehabilitation with
strength and endurance training. In addition to conventional diagnostic procedures, muscle
biopsies from the M. vastus lateralis will be conducted before and after rehabilitation
program followed by biochemical, histochemical and immunohistochemical analysis of the
probes.
Clinical Details
Official title: Effects of Exercise Training on Quadriceps Gene Expression in COPD-patients in Comparison to Alpha-1-Antitrypsin-deficiency-patients
Study design: Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
Primary outcome: aerobic and anaerobic enzymes
Secondary outcome: maximal exercise capacity in incremental cycling test6-minute-walking distance
Eligibility
Minimum age: 40 Years.
Maximum age: 75 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- COPD
- Alpha-1-Antitrypsine-deficiency, phenotype: ZZ
- FEV1%pred. <50
Exclusion Criteria:
- acute exacerbation
- exacerbation in the last 4 weeks
Locations and Contacts
Klinikum Berchtesgadener Land, Berchtesgaden 83471, Germany
Additional Information
Starting date: February 2010
Last updated: December 16, 2013
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