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Effects of Exercise Training in Chronic Obstructive Pulmonary Disease Versus Alpha-1-Antitrypsin-deficiency-patients

Information source: Klinikum Berchtesgadener Land der Schön-Kliniken
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Chronic Obstructive Pulmonary Disease; Alpha-1-antitrypsin-deficiency

Intervention: exercise training (Procedure)

Phase: N/A

Status: Completed

Sponsored by: Klinikum Berchtesgadener Land der Schön-Kliniken

Official(s) and/or principal investigator(s):
Klaus Kenn, Dr. med., Study Chair, Affiliation: Klinikum Berchtesgadener Land, Schön Klinik

Summary

Chronic Obstructive Pulmonary Disease (COPD)-patients (caused by smoking-level) and Alpha-1-Antitrypsin-deficiency patients showed different developments during rehabilitation in regard to improvement of 6-minute-walking distance. The aim of this study is to investigate differences between training adaptations in COPD-patients and Alpha-1-deficiency patients. Both groups take part in a standardized multimodal 3-week-rehabilitation with strength and endurance training. In addition to conventional diagnostic procedures, muscle biopsies from the M. vastus lateralis will be conducted before and after rehabilitation program followed by biochemical, histochemical and immunohistochemical analysis of the probes.

Clinical Details

Official title: Effects of Exercise Training on Quadriceps Gene Expression in COPD-patients in Comparison to Alpha-1-Antitrypsin-deficiency-patients

Study design: Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Primary outcome: aerobic and anaerobic enzymes

Secondary outcome:

maximal exercise capacity in incremental cycling test

6-minute-walking distance

Eligibility

Minimum age: 40 Years. Maximum age: 75 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- COPD

- Alpha-1-Antitrypsine-deficiency, phenotype: ZZ

- FEV1%pred. <50

Exclusion Criteria:

- acute exacerbation

- exacerbation in the last 4 weeks

Locations and Contacts

Klinikum Berchtesgadener Land, Berchtesgaden 83471, Germany
Additional Information

Starting date: February 2010
Last updated: December 16, 2013

Page last updated: August 23, 2015

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