Preemptive Analgesia for Postlaminectomy
Information source: Harran University
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Laminectomy
Intervention: Lidocaine, perineural injection, intraoperatively (Drug); Lidocaine (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: Harran University Official(s) and/or principal investigator(s):
cengiz Mordeniz, MD, Ass Prof, Study Chair, Affiliation: Harran University
Summary
To relieve post laminectomy pain, we have tried intraoperative perineural injection of
lidocaine right after the exposure in expecting that this would be preemptive analgesia by
blocking the nerve transmission so that postoperative pain starts later and lighter.
Clinical Details
Official title: Intraoperative Perineural Injection of Lidocaine for Postlaminectomy Pain
Study design: Prevention, Randomized, Double Blind (Subject, Investigator, Outcomes Assessor), Placebo Control, Parallel Assignment, Efficacy Study
Primary outcome: In the laminectomy operation, right after the exposure of the dorsal root , an injection of lidocaine attenuates postoperative pain.
Detailed description:
A randomized double-blind 40 patients aged 18-50 of ASA I and II undergoing laminectomy were
included in the study. All the patients were followed for their heart rate, arterial pressure
, respiratory rate, oxygen saturation, end tidal CO2 and postoperative VAS scores.
All the patients were premedicated with midazolam 0. 1 mg/kg intramuscularly 40 minutes prior
to surgery. The induction was made 2 mg/kg propofol, 1 ug/kg remifentanyl, 0. 5mg/kg
rocuronium. After the orotracheal intubation anesthesia was maintained with isoflurane
(%0. 5-2. 0) and 0. 1 mg/kg rocuronium. Just before the exposure of dorsal root, 0. 5 cc %2
lidocaine was injected on the dorsal root. The patients postoperative analgesic period, VAS
scores and additional analgesic need was recorded. For the postoperative analgesia tramadol 1
mg/kg tramadol was used.
Eligibility
Minimum age: 18 Years.
Maximum age: 50 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- laminectomy
- 18-50 age
- ASA 1-2
- both sex
Exclusion Criteria:
- under 18 or older than 50
- any disease other than back pain\
- ASA 3-4
Locations and Contacts
harran University Education, Research and application hospital, Sanliurfa 63000, Turkey
Additional Information
Starting date: September 2007
Ending date: December 2007
Last updated: April 10, 2008
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