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Effects of Acetazolamide and CO2 Inhalation on Exercise-Induced Periodic Breathing in Heart Failure

Information source: Centro Cardiologico Monzino
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Chronic Heart Failure

Intervention: acetazolamide (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: Centro Cardiologico Monzino

Official(s) and/or principal investigator(s):
Piergiuseppe Agostoni, MD, PhD, Principal Investigator, Affiliation: Centro Cardiologico Monzino

Overall contact:
Piergiuseppe Agostoni, MD, PhD, Phone: +39.025800, Ext: 2299, Email: piergiuseppe.agostoni@ccfm.it


To evaluate the effects of CO2 inhalation and acetazolamide treatment on exercise-induced periodic breathing in patients with chronic stable heart failure. Patients will be given CO2 (2%) during a constant workload exercise. Patients will be also evaluated by maximal cardiopulmonary exercise test without and with acetazolamide acute and chronic treatment.

Clinical Details

Study design: Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label

Primary outcome: Suppression of periodic breathing

Secondary outcome: suppression of sleeping apnea


Minimum age: 18 Years. Maximum age: 80 Years. Gender(s): Both.


Inclusion Criteria:

- chronic heart failure in stable clinical condition

- exercise-induced periodic breathing

Exclusion Criteria:

- comorbidities

- NYHA class IV

Locations and Contacts

Piergiuseppe Agostoni, MD, PhD, Phone: +39.025800, Ext: 2299, Email: piergiuseppe.agostoni@ccfm.it

Centro Cardiologico Monzino, University of Milan, Milan 20138, Italy; Recruiting
Piergiuseppe Agostoni, MD, PhD, Phone: +39.025800, Ext: 2299, Email: piergiuseppe.agostoni@ccfm.it
Mauro Contini, MD, Sub-Investigator
Additional Information

Related publications:

Agostoni P, Bussotti M, Cattadori G, Margutti E, Contini M, Muratori M, Marenzi G, Fiorentini C. Gas diffusion and alveolar-capillary unit in chronic heart failure. Eur Heart J. 2006 Nov;27(21):2538-43. Epub 2006 Oct 6.

Starting date: July 2007
Last updated: August 16, 2007

Page last updated: August 20, 2015

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