Effects of Acetazolamide and CO2 Inhalation on Exercise-Induced Periodic Breathing in Heart Failure
Information source: Centro Cardiologico Monzino
Information obtained from ClinicalTrials.gov on February 07, 2013
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Chronic Heart Failure
Intervention: acetazolamide (Drug)
Phase: Phase 4
Status: Recruiting
Sponsored by: Centro Cardiologico Monzino Official(s) and/or principal investigator(s):
Piergiuseppe Agostoni, MD, PhD, Principal Investigator, Affiliation: Centro Cardiologico Monzino
Overall contact:
Piergiuseppe Agostoni, MD, PhD, Phone: +39.025800, Ext: 2299, Email: piergiuseppe.agostoni@ccfm.it
Summary
To evaluate the effects of CO2 inhalation and acetazolamide treatment on exercise-induced
periodic breathing in patients with chronic stable heart failure.
Patients will be given CO2 (2%) during a constant workload exercise. Patients will be also
evaluated by maximal cardiopulmonary exercise test without and with acetazolamide acute and
chronic treatment.
Clinical Details
Study design: Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label
Primary outcome: Suppression of periodic breathing
Secondary outcome: suppression of sleeping apnea
Eligibility
Minimum age: 18 Years.
Maximum age: 80 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- chronic heart failure in stable clinical condition
- exercise-induced periodic breathing
Exclusion Criteria:
- comorbidities
- NYHA class IV
Locations and Contacts
Piergiuseppe Agostoni, MD, PhD, Phone: +39.025800, Ext: 2299, Email: piergiuseppe.agostoni@ccfm.it
Centro Cardiologico Monzino, University of Milan, Milan 20138, Italy; Recruiting
Piergiuseppe Agostoni, MD, PhD, Phone: +39.025800, Ext: 2299, Email: piergiuseppe.agostoni@ccfm.it
Mauro Contini, MD, Sub-Investigator
Additional Information
Related publications: Agostoni P, Bussotti M, Cattadori G, Margutti E, Contini M, Muratori M, Marenzi G, Fiorentini C. Gas diffusion and alveolar-capillary unit in chronic heart failure. Eur Heart J. 2006 Nov;27(21):2538-43. Epub 2006 Oct 6.
Starting date: July 2007
Last updated: August 16, 2007
|
