Benazepril for Advanced Chronic Renal Insufficiency
Information source: Southern Medical University, China
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Chronic Kidney Failure
Intervention: Benazepril (Drug)
Phase: N/A
Status: Terminated
Sponsored by: Southern Medical University, China Official(s) and/or principal investigator(s):
Fan Fan Hou, M.D.,Ph.D., Principal Investigator, Affiliation: Southern Medical University
Summary
The purpose of this study is to further determine whether benazepril, could safely slow the
progression of renal dysfunction in non-diabetic patients with advanced renal insufficiency.
Clinical Details
Study design: Treatment, Randomized, Double-Blind, Placebo Control, Single Group Assignment, Efficacy Study
Eligibility
Minimum age: 18 Years.
Maximum age: 70 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
1. serum creatinine concentration 1. 5-5. 0 mg/dL (133-442 µmol/L)
2. creatinine clearance 20 to70 mL/min/1. 73 m2, with variations of less than 30 percent
in the three months before the screening evaluation
3. non-diabetic renal disease
4. persistent proteinuria (defined as urinary protein excretion greater than 0. 3 g/day
for three or more months without evidence of urinary-tract infection or overt heart
failure [New York Heart Association class III–IV]).
Exclusion Criteria:
- immediate need for dialysis; treatment with corticosteroids, non-steroidal
anti-inflammatory drugs or immunosuppressive drugs; renovascular disease; myocardial
infarction or cerebrovascular accident in the year preceding the trial;
connective-tissue disease; obstructive uropathy.
Locations and Contacts
Additional Information
Last updated: May 4, 2006
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