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A Study of Pioglitazone and Carboplatin in Patients With Advanced Solid Tumors

Information source: Dana-Farber Cancer Institute
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Advanced Solid Tumor; Metastatic Solid Tumor

Intervention: carboplatin (Drug); pioglitazone (Drug)

Phase: Phase 1

Status: Active, not recruiting

Sponsored by: Dana-Farber Cancer Institute

Official(s) and/or principal investigator(s):
James Cleary, MD, PhD, Principal Investigator, Affiliation: Dana Farber Cancer Instiute

Summary

The proposed investigation is a Phase 1 trial to determine the safety, tolerability, and maximum tolerated dose (MTD) of the combination of pioglitazone ( and carboplatin patients with advanced or metastatic solid malignancies.

Clinical Details

Official title: A Phase I Study of Pioglitazone and Carboplatin in Patients With Advanced Solid Tumors

Study design: Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: MTD of pioglitazone and carboplatin

Secondary outcome:

Plasma Concentration-time Profiles

Induction Rate of metallothionein expression and DNA damage by carboplatin in the absence or presence of pioglitazone.

Anti-Tumor Response and Progression Rate

Detailed description:

- In Part I of the study, the maximum tolerated dose (MTD) will be determined. During

part I, Cycle 1, days 1-28, pioglitazone will be administered once daily. On cycle 1, day 8, the first dose of carboplatin will be administered. On cycle 2, day 1, both carboplatin and pioglitazone will be administered. Cycles 2 and onward are 21-day cycles, with pioglitazone administered once daily and carboplatin administered once every 3 weeks. Part I of the study will end when the MTD has been determined in a minimum of 6 patients.

- In Part II of the trial, an MTD Expansion Cohort may be utilized to further

characterize the safety profile and pharmacodynamics of the drug. Patients in the MTD Expansion Cohort will receive carboplatin alone on cycle 1, day 1. Over days 15-21 of the cycle pioglitazone will be administered alone. On cycle 2, day 1, both carboplatin and pioglitazone will be administered. Cycle 2 and onward are 21-day cycles, with pioglitazone administered once daily and carboplatin administered once every 3 weeks.

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Histologically confirmed malignancy that is not curable with standard approaches and

where carboplatin is appropriate therapy.

- During Part I of the trial (MTD determining phase), measurable or evaluable disease

is acceptable. For Part II of the trial (expanded cohort) only, participants must have measurable disease by RECIST criteria version 1. 1.

- Participants enrolled in Part II of the trial (expanded cohort) must have disease

that is amenable to biopsy with reasonable safety and also be willing to undergo at least two serial tumor biopsies for correlative biomarker investigation as defined in Section 8. 2.2.

- Any number of prior therapies are permitted. Prior carboplatin is allowed. Patients

who have documented allergy to carboplatin may receive carboplatin with desensitization.

- Age ≥18 years old.

- ECOG performance status ≤ 1 (Appendix A).

- Participants must have normal organ and marrow function as defined below:

- Absolute neutrophil count ≥1,500/L

- Hematocrit ≥ 27

- Platelets ≥100,000/L

- Total bilirubin within normal institutional limits

- AST (SGOT)/ALT (SGPT)≤ 2. 5 X institutional upper limit of normal

- Creatinine within normal institutional limits or creatinine clearance ≥ 60

mL/min/1. 73 m2 for subjects with creatinine levels above institutional normal.

- Able to swallow oral medication.

- Women of child-bearing potential and men must agree to use adequate contraception

(hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation.

- Ability to understand and the willingness to sign a written informed consent

document. Exclusion Criteria: Participants who exhibit any of the following conditions at screening will not be eligible for admission into the study.

- Subjects who have been treated with standard chemotherapy or molecularly targeted

agents within the past 3 weeks prior to trial first drug administration.

- Subjects who were receiving experimental therapies must wait 3 weeks from their last

dose prior to enrolling. Subjects treated with nitrosoureas or mitomycin C cannot be enrolled until 6 weeks has elapsed since their last treatment.

- Extensive prior radiotherapy on more than 25% of the bone marrow, or prior bone

marrow/stem cell transplantation. Prior radiation for local disease management is allowed if last fraction was completed at least 4 weeks prior to trial entry.

- Subjects who have undergone a major surgical procedure within the 6 weeks prior to

trial entry.

- History of untreated central nervous system (CNS) metastases. Subjects with a history

of prior treated brain metastasis are eligible provided that 1 month following treatment they are stable by CT scan without evidence of cerebral edema, and have no requirements for corticosteroids.

- Diabetic patients who are currently requiring oral hypoglycemic agents or insulin

therapy.

- Patients who are currently receiving rosiglitazone or pioglitazone, or who have

received dosing with any other agent known to be a PPAR agonist within 3 months prior to study entry.

- Left ventricular ejection fraction ≤ 50% on ECHO or MUGA

- Uncontrolled concomitant illness including, but not limited to ongoing or active

infection, symptomatic congestive heart failure, unstable angina pectoris, uncontrolled cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.

- Pregnant or nursing women.

- Known HIV positivity, active hepatitis C, or active hepatitis B.

- Patients with ≥ CTCAE Grade 2 peripheral neuropathy.

- Subjects with a known history of gastrointestinal disorder (such as partial

esophageal, gastric, small or large bowel obstruction), surgery or malabsorption that could potentially impact the swallowing or the absorption of the study drug.

- Patients taking CYP2C8 inhibitors and inducers (rifampin, gemfibrozil, trimethoprim,

montelukast, and quercetin) are excluded from the trial.

- Other significant disease that in the Investigator's opinion would exclude the

subject from the trial.

Locations and Contacts

Brigham and Women's Hospital, Boston, Massachusetts 02215, United States

Dana-Farber Cancer Institute, Boston, Massachusetts 02115, United States

Additional Information

Starting date: August 2011
Last updated: May 6, 2014

Page last updated: August 23, 2015

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