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The Effect of Niacin Administration on Oxidative Stress in Patients With Hypercholesterolmia, as Measured by the Use of a Novel Biomarker

Information source: Rambam Health Care Campus
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Hypercholesterolemia

Intervention: Niacin\Laropiprant (Drug)

Phase: Phase 3

Status: Not yet recruiting

Sponsored by: Rambam Health Care Campus

Official(s) and/or principal investigator(s):
Liz Phima, Study Director, Affiliation: Study Coordinator

Overall contact:
Shadi Hamoud, Dr, Phone: +972-523591876, Email: s_hamoud@rambam.health.gov.il


1. Treatment of Hypercholesterolemic patients with niacin will cause a significant decrease in oxidative stress and a decrease in the atherogenecity in blood samples of the patients. 2. A possible correlation between oxidative stress in hypercholesterolemic patients taking niacin to clinical hypercholesterolemia parameters is possible. 3. Using a novel biomarker will enable a precise detection of the change in the oxidative stress in hypercholesterolemic patients.

Clinical Details

Study design: Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Effect on oxidative stress


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Hypercholesterolemia,

- age above eighteen

Exclusion Criteria:

- Treatment with fibrates,

- Pregnant/Breast feeding women

Locations and Contacts

Shadi Hamoud, Dr, Phone: +972-523591876, Email: s_hamoud@rambam.health.gov.il

Rambam Health Care Campus, Haifa 31096, Israel; Not yet recruiting
Shadi, Phone: +972-523591876, Email: s_hamoud@rambam.health.gov.il
Tony Hayek, Prof, Phone: +972-523782009, Email: t_hayek@rambam.health.gov.il
Tony Hayek, Prof, Sub-Investigator
Additional Information

Starting date: April 2010
Last updated: February 25, 2010

Page last updated: August 23, 2015

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