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Magnetoencephalographic (MEG) Localization of Ramelteon's Effects on Brain Function and Cortical Arousal in Insomnia

Information source: Henry Ford Health System
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Insomnia

Phase: N/A

Status: Completed

Sponsored by: Henry Ford Health System

Official(s) and/or principal investigator(s):
Christopher Drake, Ph.D., Principal Investigator, Affiliation: Henry Ford Hospital Sleep Disorders & Research Center

Summary

The present protocol will utilize simultaneous recording of brain activity during attention and memory tasks in insomnia participants after ramelteon vs. zolpidem vs. placebo administration. The investigators hypothesize that amplitudes of associated with memory will be unchanged by ramelteon, whereas zolpidem will significantly reduce brain activity associated with stimulus processing as evidenced by abnormal reduction in the amplitude of specific brain regions relative to placebo.

Clinical Details

Official title: Magnetoencephalographic Localization of Ramelteon's Effects on Brain Function and Cortical Arousal in Insomnia

Study design: Time Perspective: Cross-Sectional

Detailed description: The proposed research has two specific aims: 1) demonstrate that ramelteon has no effect on event related potential components that reflect basic sensory processes (P1 and N1), and will not impair attention and memory processes, whereas the benzodiazepine receptor agonist zolpidem will significantly reduce (relative to placebo) the amplitude of these event related potential components throughout the cerebral cortex and 2) show that ramelteon reduces the abnormal hyperarousal in insomnia as reflected through a reduction in the contingent negative variation component of the event related potential across frontal and parietal brain regions.

Eligibility

Minimum age: 18 Years. Maximum age: 55 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Healthy individuals with no secondary condition to insomnia.

Exclusion Criteria:

- Healthy individuals with no insomnia.

Locations and Contacts

Henry Ford Hospital Sleep Disorders & Research Center, Detroit, Michigan 48202, United States
Additional Information

Starting date: May 2008
Last updated: March 30, 2010

Page last updated: August 23, 2015

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