Magnetoencephalographic (MEG) Localization of Ramelteons Effects on Brain Function and Cortical Arousal in Insomnia
Information source: Henry Ford Health System
Information obtained from ClinicalTrials.gov on October 19, 2009
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Insomnia
Phase: N/A
Status: Recruiting
Sponsored by: Henry Ford Health System Official(s) and/or principal investigator(s):
Christopher Drake, Ph.D., Principal Investigator, Affiliation: Henry Ford Hospital Sleep Disorders & Research Center
Summary
The present protocol will utilize simultaneous recording of brain activity during attention
and memory tasks in insomnia participants after ramelteon vs. zolpidem vs. placebo
administration. The investigators hypothesize that amplitudes of associated with memory
will be unchanged by ramelteon, whereas zolpidem will significantly reduce barin activity
associated with stimulus processing as evidenced by abnormal reduction in the amplitude of
specific brain regions relative to placebo.
Clinical Details
Official title: Magnetoencephalographic Localization of Ramelteon's Effects on Brain Function and Cortical Arousal in Insomnia
Study design: Other, Cross-Sectional
Detailed description:
The proposed research has two specific aims: 1) demonstrate that ramelteon has no effect on
event related potential components that reflect basic sensory processes (P1 and N1), and
will not impair attention and memory processes, whereas the benzodiazepine receptor agonist
zolpidem will significantly reduce (relative to placebo) the amplitude of these event
related potential components throughout the cerebral cortex and 2) show that ramelteon
reduces the abnormal hyperarousal in insomnia as reflected through a reduction in the
contingent negative variation component of the event related potential across frontal and
parietal brain regions.
Eligibility
Minimum age: 18 Years.
Maximum age: 55 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Healthy individuals with no secondary condition to insomnia.
Exclusion Criteria:
- Healthy individuals with no insomnia.
Locations and Contacts
Henry Ford Hospital Sleep Disorders & Research Center, Detroit, Michigan 48202, United States; Recruiting
Christopher Drake, Ph.D., Phone: 313-916-4455
Christopher Drake, Ph.D., Principal Investigator
Additional Information
Starting date: May 2008
Ending date: September 2009
Last updated: January 29, 2009
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