Pathophysiology of Orthostatic Intolerance
Information source: Vanderbilt University
Information obtained from ClinicalTrials.gov on October 19, 2009
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Tachycardia; Postural Orthostatic Tachycardia Syndrome
Intervention: DAXOR (Radiation); QSweat (Procedure); Intrinsic Heart Rate (Drug)
Phase: N/A
Status: Recruiting
Sponsored by: Vanderbilt University Official(s) and/or principal investigator(s):
David Robertson, MD, Principal Investigator, Affiliation: Vanderbilt University
Overall contact:
Bonnie K Black, BSN CNP, Phone: 615-343-6499, Email: adc.research@vanderbilt.edu
Summary
The purpose of this study is to describe the mechanism of orthostatic intolerance, relying
on cardiovascular physiological studies. The syndrome is of undetermined etiology, but the
syndrome causes impairment of a number of young adults, females more than males, with
symptoms of tachycardia, fatigue, lightheadedness, palpitations, blurred vision, chest
discomfort, difficulty concentrating, and dizziness with the upright posture. It is believed
that many different pathophysiological processes can give rise to this disorder.
Clinical Details
Official title: Pathophysiology of Orthostatic Intolerance
Study design: Diagnostic, Non-Randomized, Open Label, Uncontrolled, Parallel Assignment
Primary outcome: Physiological abnormalities in orthostatic intolerance
Secondary outcome: blood volumeintrinsic heart rate quantitative sweat testing residual sympathetic function after pharmacological autonomic blockade norepinephrine spillover
Eligibility
Minimum age: 18 Years.
Maximum age: 80 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Orthostatic intolerance
Exclusion Criteria:
- Inability or unwillingness to give informed consent
Locations and Contacts
Bonnie K Black, BSN CNP, Phone: 615-343-6499, Email: adc.research@vanderbilt.edu
Vanderbilt University, Nashville, Tennessee 37232, United States; Recruiting
David Robertson, M.D., Principal Investigator
Italo Biaggioni, MD, Sub-Investigator
Satish R Raj, MD MSCI, Sub-Investigator
Additional Information
Website of the Vanderbilt Autonomic Dysfunction Center
Starting date: December 1996
Ending date: December 2011
Last updated: September 1, 2009
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