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Pathophysiology of Orthostatic Intolerance

Information source: Vanderbilt University
Information obtained from ClinicalTrials.gov on December 08, 2011
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Tachycardia; Postural Orthostatic Tachycardia Syndrome

Intervention: DAXOR (Radiation); QSweat (Procedure); Intrinsic Heart Rate (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: Vanderbilt University

Official(s) and/or principal investigator(s):
David Robertson, MD, Principal Investigator, Affiliation: Vanderbilt University

Overall contact:
Bonnie K Black, BSN CNP, Phone: 615-343-6499, Email: adc.research@vanderbilt.edu

Summary

The purpose of this study is to describe the mechanism of orthostatic intolerance, relying on cardiovascular physiological studies. The syndrome is of undetermined etiology, but the syndrome causes impairment of a number of young adults, females more than males, with symptoms of tachycardia, fatigue, lightheadedness, palpitations, blurred vision, chest discomfort, difficulty concentrating, and dizziness with the upright posture. It is believed that many different pathophysiological processes can give rise to this disorder.

Clinical Details

Official title: Pathophysiology of Orthostatic Intolerance

Study design: Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Primary outcome: Physiological abnormalities in orthostatic intolerance

Secondary outcome:

blood volume

intrinsic heart rate

quantitative sweat testing

residual sympathetic function after pharmacological autonomic blockade

norepinephrine spillover

Eligibility

Minimum age: 18 Years. Maximum age: 80 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Orthostatic intolerance

Exclusion Criteria:

- Inability or unwillingness to give informed consent

Locations and Contacts

Bonnie K Black, BSN CNP, Phone: 615-343-6499, Email: adc.research@vanderbilt.edu

Vanderbilt University, Nashville, Tennessee 37232, United States; Recruiting
David Robertson, M.D., Principal Investigator
Italo Biaggioni, MD, Sub-Investigator
Satish R Raj, MD MSCI, Sub-Investigator
Additional Information

Website of the Vanderbilt Autonomic Dysfunction Center

Starting date: December 1996
Last updated: June 24, 2011

Page last updated: December 08, 2011

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