Nebivolol Versus Bisoprolol Versus Carvedilol in Heart Failure
Information source: Centro Cardiologico Monzino
Information obtained from ClinicalTrials.gov on October 19, 2009
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Chronic Heart Failure
Intervention: carvedilol (Drug); bisoprolol (Drug); Nebivolol (Drug)
Phase: Phase 4
Status: Recruiting
Sponsored by: Centro Cardiologico Monzino Official(s) and/or principal investigator(s):
Piergiuseppe Agostoni, MD, PhD, Principal Investigator, Affiliation: Centro Cardiologico Monzino
Giancarlo Marenzi, MD, Study Chair, Affiliation: Centro Cardiologico Monzino
Overall contact:
Piergiuseppe Agostoni, MD, PhD, Phone: +39.025800, Ext: 2299, Email: piergiuseppe.agostoni@ccfm.it
Summary
We test the hypothesis that different beta-blockers had a different influence on
chemoreceptor response and lung diffusion capacity.
Both could influence exercise capacity in normoxic as well as hypoxic conditions.
Clinical Details
Official title: Nebivolol Versus Bisoprolol Versus Carvedilol in Heart Failure: Effects on Exercise Capacity and Hypoxia, Chemoreceptor Response, Pulmonary Function
Study design: Treatment, Randomized, Single Blind (Investigator), Active Control, Crossover Assignment, Efficacy Study
Primary outcome: exercise capacity
Secondary outcome: lung diffusion
Eligibility
Minimum age: 18 Years.
Maximum age: 80 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Chronic heart failure patients in stable clinical condition
Exclusion Criteria:
- No comorbidity
- NYHA class IV
Locations and Contacts
Piergiuseppe Agostoni, MD, PhD, Phone: +39.025800, Ext: 2299, Email: piergiuseppe.agostoni@ccfm.it
Centro Cardiologico Monzino, University of Milan, Milan 20138, Italy; Recruiting
Piergiuseppe Agostoni, MD, PhD, Phone: +39.025800, Ext: 2299, Email: piergiuseppe.agostoni@ccfm.it
Additional Information
Related publications: Agostoni P, Bussotti M, Cattadori G, Margutti E, Contini M, Muratori M, Marenzi G, Fiorentini C. Gas diffusion and alveolar-capillary unit in chronic heart failure. Eur Heart J. 2006 Nov;27(21):2538-43. Epub 2006 Oct 6.
Starting date: July 2007
Ending date: August 2009
Last updated: August 16, 2007
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