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Niacin Skin Flush Response in Patients With Schizophrenia

Information source: Isfahan University of Medical Sciences
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Schizophrenia

Intervention: Niacin skin test (Biological)

Phase: Phase 2/Phase 3

Status: Completed

Sponsored by: Isfahan University of Medical Sciences

Official(s) and/or principal investigator(s):
Maryam Tabatabaeian, MD, Principal Investigator, Affiliation: Isfahan University of Medical Sciences


Patients with schizophrenia have abnormal skin flush response to niacin, but the niacin skin test accuracy is not well studied in these patients. The study evaluated the niacin skin test accuracy in adult hospitalized schizophrenia patients and their first degree relatives, bipolar disorder patients, and healthy controls.

Clinical Details

Official title: Niacin Skin Flush Response in Patients With Schizophrenia, Their First Degree Relatives, Bipolar Disorder Patients, and Healthy Controls

Study design: Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Diagnostic

Primary outcome: Skin flush response


Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.


Inclusion Criteria:

- Diagnosis of schizophrenia patients and bipolar disorder patients diagnosed according

to the Diagnostic and Statistical Manual of Mental Disorders version IV criteria

- Normal healthy subjects without a psychiatric history

- First degree relatives of schizophrenic patients

Exclusion Criteria:

- Dermatological lesions, asthma or allergic disease, diabetes, chronic hypertension,

vasculitis, substance use disorders (except cigarette smoking), or pregnancy

- Taking any oral medication that could affect the metabolism of prostaglandins such as

nonsteroidal anti-inflammatory drugs or corticosteroids

Locations and Contacts

Additional Information

Starting date: January 2014
Last updated: May 30, 2015

Page last updated: August 23, 2015

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