DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



The Effect of Propofol Infusion on Total Antioxidant Status During Tourniquet-Induced Ischemia-Reperfusion Injury

Information source: Diskapi Teaching and Research Hospital
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Total Knee Arthroplasty; Tourniquet-Induced Ischemia-Reperfusion Injury

Intervention: Propofol (Drug); Placebo (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: Diskapi Teaching and Research Hospital

Official(s) and/or principal investigator(s):
Derya Özkan, MD, Principal Investigator, Affiliation: Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Anesthesiology Clinic
Taylan Akkaya, MD, Study Chair, Affiliation: Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Anesthesiology Clinic
Ali Yalcindag, MD, Study Chair, Affiliation: Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Biochemistry Clinic
Tuba Hanci, MD, Study Chair, Affiliation: Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Biochemistry Clinic
Haluk Gümüs, MD, Study Chair, Affiliation: Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Anesthesiology Clinic
Namik Delibas, MD, Study Chair, Affiliation: Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Biochemistry Clinic

Overall contact:
Derya Özkan, MD, Phone: +903125962553, Email: derya_z@yahoo.com

Summary

The release of tourniquet produces reactive oxygen species which can cause injury. Propofol is chemically similar to phenol-based free radical scavengers. Plasma total antioxidant capacity is a well-established marker of the overall protective effect of antioxidants in body fluids. The aim of the study is to investigate the effects of propofol on ischemia-reperfusion injury in total knee arthroplasty (TKA).

Clinical Details

Official title: The Effect of Propofol Infusion on Total Antioxidant Status During Tourniquet-Induced Ischemia-Reperfusion Injury in Total Knee Arthroplasty

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Prevention

Primary outcome: The perioperative alternation of the venous blood total antioxidant capacity levels of the arms

Eligibility

Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- ASA I-II physical status

- Unilateral total knee arthroplasty

- Age 18 years to 65 years

Exclusion Criteria:

- Severe central nervous system disorders

- Severe cardiopulmonary,renal,metabolic, or hepatic disease,

- Blood volume deficits,

- Coagulopathy,

- Allergy to local anesthetics,

- Peripheral neuropathies,

- Body mass index > 35,

- History of antioxidant drug use

Locations and Contacts

Derya Özkan, MD, Phone: +903125962553, Email: derya_z@yahoo.com

Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Anesthesiology and Biochemistry Clinics, Ankara 06110, Turkey; Recruiting
Derya Özkan, MD, Phone: +903125962553, Email: derya_z@yahoo.com
Additional Information

Starting date: June 2012
Last updated: July 11, 2012

Page last updated: August 20, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017